Vectors for gene transfer

Details Vectors for gene transfer Vectors for gene transfer

1994-03-14

2000-02-22

Priebe, Scott D.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

514 44, 536 231, 435 6, 435 691, 4353201, 435325, 435455, A61K 4800, A01N 6300, C12N 1500

Patent

active

06027722&

ABSTRACT:
Improved recombinant retrotransposon vectors for gene transfer are disclosed. The synthetic vectors are truncated so as to reduce or altogether eliminate homologous recombination with retroviral helper sequences found in helper cells used to propagate the vectors, making them safer for use in humans and providing more space for therpeutic genes. The vectors transmit foreign DNA efficiently, are stable, enable abundant RNA expression from the retrotransposon transcriptional promoter, and through their diversity permit many useful applications in therapeutics and transgenics. Methods are described for rescuing tissue-specific spromoters obtaining expression in primary cells, mapping the genome and other techniques of therapeutic and transgenic utility.

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