Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1996-03-25
1999-07-27
Ketter, James
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4353201, 4353723, 536 231, 536 235, 536 2372, C12N 1563, C12N 508, C07H 2104
Patent
active
059289139
ABSTRACT:
Herpesvirus amplicon preparations comprise an origin of replication, a packaging sequence, and at least one inserted gene under control of a promoter, suitable for use as an immunogen or vaccine, in association with helper herpesvirus or DNA, wherein the associated helper virus is of restricted replication competence in a normal host cell; for example where the associated helper virus has an inactivating defect in respect of a gene essential for production of infectious new virus particles, and where the amplicon carries an inserted gene necessary for the propagation of the helper virus.
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Efstathiou Stacey
Inglis Stephen C.
Zhang Xiaoliu
Dreger Walter H.
Ketter James
Sandals William
Silva Robin M.
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