Vectors for expression of globin genes

Details Vectors for expression of globin genes Vectors for expression of globin genes

1997-02-26

2000-02-08

Crouch, Deborah

Chemistry: molecular biology and microbiology

Vector, per se

435325, 435455, 435456, C12N 1500, C12N 500

Patent

active

060227389

ABSTRACT:
The present invention relates to vectors comprising an .alpha.-globin locus control region (.alpha.LCR) and a gene encoding an erythroid protein. In articular embodiments, a retroviral vector comprising an .alpha.LCR and a globin gene may be used to treat globin-based genetic disorders, including sickle cell anemia and .beta.-thalassemia.

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