Vectors for animal cells and utilization thereof

Details Vectors for animal cells and utilization thereof Vectors for animal cells and utilization thereof

2006-06-20

2006-06-20

Guzo, David (Department: 1633)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C514S04400A, C435S320100, C435S325000

Reexamination Certificate

active

07064194

ABSTRACT:
Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a gene encoding a ribosome-constituting protein derived from an animal. The genes may be placed in recombinant vectors, including expression vectors containing the gene together with a foreign protein structural gene.

REFERENCES:
Mutoh, E. et al., “Inducible Expression of a Gene Encoding an L41 Ribosomal Protein Responsible for the Cycloheximide-Resistant Phenotype in the YeastCandida maltosa”, 1995, J. Bacteriol., vol. 177: pp. 5383-5386.
Rhoads, D.D. et al., “Emetine Resistance of Chinese Hamster Cells: Structures of Wild-Type and Mutant Ribosomal Protein S14 mRNAs”, 1985, Mol. Cell. Biol., vol. 5: pp. 1655-1659.
Supplementary Partial European Search Report of EP 02 70 2844.
D.R. Stevens et al., “Cycloheximide resistance conferred by novel mutations in ribosomal protein L41 ofChlamydomonas reinhardtii”, Mol. Gen. Genet. (2001), 264: 790-795.
Bradley J. Blitvich et al., “Molecular Cloning and Complete cDNA Sequence of the Ribosomal Proteins rpL34 and rpL44 fromAedes TriseriatusMosquitoes”, DNA Sequence, vol. 11(5), pp. 451-455.
Carolyn L. Jahn et al., “Sequence of the macronuclear DNA encoding large subunit ribosomal protein 29 (L29) inEuplotes crassusand cycloheximide sensitivity”, Gene, 151 (1994), 231-235.
Lourdes Del Pozo et al., “Cycloheximide resistance as a yeast cloning marker”, Curr Genet (1991), pp. 353-358.

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