Vectors carrying therapeutic genes encoding antimicrobial...

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing

Reexamination Certificate

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C424S093200, C424S093210, C435S320100, C435S325000, C435S440000, C435S455000, C514S04400A

Reexamination Certificate

active

07022319

ABSTRACT:
The present invention relates to recombinant vectors carrying sequences encoding naturally occurring antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours and viral infections such as HIV infections and bacterial and fungal infections. In particular the present invention relates to retroviral vectors. Furthermore, the present invention relates to retroviral vectors which undergo promoter conversion (Procon vectors) carrying such sequences. Since these vectors also carry tumour or virus specific regulatory elements, the therapeutic antimicrobial peptide will be delivered and expressed only in relevant, affected cells and not in innocent bystander cells.

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