Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2006-05-09
2006-05-09
Scheiner, Laurie (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C435S320100, C435S236000
Reexamination Certificate
active
07041300
ABSTRACT:
The vectors comprise a recombinant defective viral genome expressing at least one antigen suitable for the induction of systemic and secretory immune responses or an antibody conferring protection against an infectious agent. The defective viral genome comprises the genome of a parental virus having the viral replicase recognition signals located on ends 3′ and 5′, further comprising internal deletions, and wherein said defective viral genome depends on a helper virus for its replication and encapsidation. These vectors are suitable for the forming of a recombinant system comprising the aforesaid expression vector, and a helper virus. The system is suitable for the manufacture of mono- and polyvalent vaccines against infectious agents of different animal species, especially pigs, dogs and cats, and as expression vehicles for antibodies protective against infectious agents.
REFERENCES:
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Van der Most, et al., A Domain at the 3'End of the Polymerase Gene Is Essential for Encapsidation of the Coronavirus Defective Interfering RNAs, J. Virol. vol. 65, No. 6, pp. 3219-26.
Chang, et al., Acis-Acting Function for the Coronavirus Leader in Defective Interfering RNA Replication, J. Virol., vol., vol. 68, No. 12, pp. 8223-31 (1994).
Médez, et al. Structure and Encapisdation of Transmissible Gastroenteritis Coronavirus (TGEV) Defective Interfering Genomes, adv. Exp. Med. and Biol. vol. 380, pp. 583-89 (1995).
Liaom et al., Coronavirus Defective-Interfering RNA as an Expression Vector: The Generation of a Pseudorecombinant Mouse Hepatitis Virus Expressing Hemagglutinin-Esterase, Virol., vol. 208, pp. 319-27 (1995).
Médez, et al., Molecular Characterization of Transmissible Gastroenteritis Coronavirus Defective Interfering Genomes: Packaging and Hetergeneity, Virol. vol. 217, pp. 495-507 (1996).
International Search Report for PCT/ES 97/00059.
Castrillon Joaquin Castilla
Duran Juan Plana
Gurpegui Isabel Sola
Jarreno MaLuisa Ballesteros
Martinez José Manuel Gonzalez
Cyanamid Iberica, S.A.
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Parkin Jeffrey S.
Scheiner Laurie
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