Vectors and vector systems including genes encoding tumor suppre

Details Vectors and vector systems including genes encoding tumor suppre Vectors and vector systems including genes encoding tumor suppre

1993-12-13

1997-12-23

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 9133, 4352351, 435325, C12P 2102, C12P 1934, C12N 510, C12N 701

Patent

active

057006571

ABSTRACT:
Vectors and vector systems are embodied that include a gene encoding a tumor suppressor protein. In one embodiment, the vector includes a gene encoding a tumor suppressor protein and an inducible promoter controlling the gene encoding a tumor suppressor protein. The tumor suppressor protein may be p53 protein. In another embodiment, there is provided a vector system which comprises a first vector including a gene encoding a tumor suppressor protein, and a second vector containing a nucleic acid sequence encoding an antisense sequence complementary to all or a portion of the gene encoding a tumor suppressor protein. In yet another embodiment, there is provided a vector system which comprises a first vector including a gene encoding a tumor suppressor protein, and a second vector containing a gene which encodes a protein which binds to, and thereby inhibits, the tumor suppressor protein. Such vectors and vector systems enable cells transformed thereby to continue to proliferate such that adequate amounts of infectious viral particles, generated from viral vectors including a gene encoding a tumor suppressor protein, can be harvested for administration to patients.

REFERENCES:
patent: 4966847 (1990-10-01), McCormick et al.
patent: 5087617 (1992-02-01), Smith
Bosselman et al. "Replication-Defective Chimeric Helper Proviruses and Factors Affecting Generation of Competent Virus: Expression of Moloney Murine Leukemia Virus Structural Genes via the Metallothionein Promoter", Mol. Cell. Biol., May 1987, pp. 1797-1806, vol. 7, No. 5.
Chen et al. "Genetic Mechanisms of Tumor Suppression by the Human p53 Gene", Science, vol. 250, Dec. 1990, pp. 1576-1580.

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