Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2011-02-01
2011-02-01
Mosher, Mary E (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C435S410000, C435S411000, C435S414000, C435S417000, C435S252300, C536S023720, C800S295000, C800S317200, C800S317300, C800S317400
Reexamination Certificate
active
07879338
ABSTRACT:
The present invention relates to a synthetic plant-optimized nucleic acid molecule having a Norwalk virus capsid protein coding nucleotide sequence, and nucleic acid constructs, host cells, expression systems, and plants having the plant-optimized Norwalk virus nucleic acid molecule. The present invention also relates to a method of producing Norwalk virus capsid protein virus-like particles in a transgenic plant or transgenic plant seed transformed with a plant-optimized nucleic acid molecule encoding Norwalk virus capsid protein. The plant or a component thereof can be administered to a subject under conditions effective to immunize the subject against disease resulting from infection by aNorovirus, including Norwalk virus. An oral vaccine for immunization of a subject against Norwalk virus infection is also disclosed.
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Arntzen Charles J.
Hamilton William D.O.
Hellendoorn Koen
Jones Timothy D.
Kirk Dwayne D.
Boyce Thompson Institute For Plant Research
Hill Myron G
Mosher Mary E
Nixon & Peabody LLP
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