Vectors and methods for gene transfer to cells

Details Vectors and methods for gene transfer to cells Vectors and methods for gene transfer to cells

1995-11-28

1999-10-12

Ketter, James

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 691, 4353201, 435367, 435379, 435370, 435456, 530350, 536 234, 536 2372, A01N 4304

Patent

active

059655410

ABSTRACT:
The present invention provides a chimeric adenovirus coat protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence. Such a chimeric adenovirus coat protein according to the invention is able to direct entry into cells of a vector comprising the coat protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus coat protein rather than the chimeric adenovirus coat protein. The chimeric coat protein preferably is a fiber, hexon, or penton protein. The present invention also provides an adenoviral vector that comprises the chimeric adenovirus coat protein, as well as methods of constructing and using such a vector.

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