Chemistry: molecular biology and microbiology – Vector – per se
Patent
1992-11-13
1994-09-20
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Vector, per se
435 693, 4351723, 4352401, 4352523, 43525233, 536 235, C12N 1512, C12N 1570
Patent
active
053488873
ABSTRACT:
The present invention comprises novel recombinant DNA compounds which encode the .about.40,000 dalton adenocarcinoma antigen recognized by monoclonal antibody KS 1/4. Eukaryotic and prokaryotic expression vectors have been constructed that comprise novel KSA-encoding DNA and drive expression of KSA when transformed into an appropriate host cell. The novel expression vectors can be used to produce KSA derivatives, such as non-glycosylated KSA, and to produce KSA precursors, such as nascent KSA, and to produce subfragments of KSA. The recombinant-produced KSA is useful for the diagnosis, prognosis and treatment of disease states including adenocarcinomas of the lung, prostate, breast, ovary and colon/rectum; and for the creation of novel antibodies for treatment or diagnosis of the above.
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Bumol Thomas F.
Gadski Robert A.
Hamilton Amy E.
Sportsiman J. Richard
Strnad Joann
Dahling Gerald V.
Eli Lilly and Company
LeGuyader J.
Maciak Ronald S.
Norman Douglas K.
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