Vectors and compounds for expression of human protein C

Details Vectors and compounds for expression of human protein C Vectors and compounds for expression of human protein C

1985-02-08

1988-10-04

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 68, 435 70, 4351723, 43524025, 435253, 435320, 435832, 435849, 435886, 935 14, 935 29, 935 32, 536 27, C12N 964, C12N 1500, C12P 2100, C07H 1512

Patent

active

047756241

ABSTRACT:
The present invention comprises novel DNA compounds which encode human protein C activity. A variety of eukaryotic and prokaryotic recombinant DNA expression vectors have been constructed that comprise the novel protein C activity-encoding DNA and drive expression of protein C activity when transformed into an appropriate host cell. The novel expression vectors can be used to produce protein C derivatives, such as non-carboxylated, non-glycosylated, or non-hydroxylated protein C, and to produce protein C precursors, such as nascent or zymogen protein C, and to produce sub-fragments of protein C, such as active or inactive light and heavy chain. The recombinant-produced protein C activity is useful in the treatment and prevention of a variety of vascular disorders.

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D. Foster and E. Davie, 1984, Proc. Natl. Acad. Sci. U.S.A. 81: 4766.
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