Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1987-12-04
1991-02-12
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4351723, 4352401, 4352402, 435254, 4353201, 536 27, C12N 964, C12N 1557, C12N 1585, C12N 1579
Patent
active
049923730
ABSTRACT:
A method for the direct recombinant production of activated protein C is described. DNA compounds, vectors, and transformants useful in the method are also disclosed. The method involves transformation and culture of a host cell with a recombinant DNA vector that encodes a protein C molecule in which the activation peptide is replaced with a cleavage sequence for a cell associated protease.
REFERENCES:
patent: 4603105 (1986-07-01), Kaplan
patent: 4696895 (1987-09-01), Yamashita et al.
patent: 4769326 (1988-09-01), Rutter
patent: 4775624 (1988-10-01), Bang et al.
Bang Nils U.
Ehrlich Hartmut
Grinnell Brian W.
Jaskunas S. Richard
Eli Lilly and Company
Lebovitz Richard M.
Norman Douglas K.
Schwartz Richard A.
Whitaker Leroy
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