Vector vaccines of bovine herpesvirus I

Details Vector vaccines of bovine herpesvirus I Vector vaccines of bovine herpesvirus I

1994-11-23

1999-02-23

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4242051, 4242291, 4241991, 536 2372, C12N 701, A61K 39245, C07H 2104

Patent

active

058742808

ABSTRACT:
The present invention is concerned with a Bovine Herpesvirus I (BHV-I) mutant comprising a heterologous gene introduced into a section of the BHV-I genome. The invention also relates to a vector vaccine comprising such a BHV-I mutant which expresses a heterologous polypeptide derived from a bovine pathogen and induces an adequate immune response in an inoculated host against both FHV an the bovine pathogen. Furthermore, the invention relates to a method for obtaining a BHV-I mutant by self-selection.

REFERENCES:
J. Audonnet, Protein Indentification Resource, Ab. No. S35785, 22-Nov.-1993.
S.K. Tikoo et al., "Analysis of Bovine Herpesvirus 1 Glycoprotein gIV Truncations and Deletions Expressed by Recombinant Vaccinia Viruses," Journal of Virology, 67:4:2103-2109, Apr. 1993.
Leung-Tack et al. "The Complete DNA Sequence and the Genetic Organization of the Short Unique Region . . . " Virology 199, 409-421 (1994).
Fehler et al. "Glycoprotein IV of Bovine Herpesvirus 1--Expressing Cell Line Complements . . . " J Virol 66(2) Feb. 1992 pp. 831, 839.
Ramshaw et al. "Cytokine Expression by Recombinant Viruses . . . " TIBTECH vol. 10, Dec. 1992, pp. 424-426.

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