Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1993-11-24
1997-12-02
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
4353201, 4351723, 424 931, C12N 1564, C12N 1585, C12N 1586, C12N 1509
Patent
active
056935315
ABSTRACT:
A vector system comprising a first vector, which is an adeno-associated viral vector, and which includes an adeno-associated virus 5'ITR, an adeno-associated virus 3'ITR, and at least one heterologous DNA sequence. The vector system also includes a second vector which includes an inducible origin of replication, such as an SV40 origin of replication, which is capable of being induced or activated by an agent, such as the SV40 T-antigen. The second vector also includes DNA sequences encoding the adeno-associated virus rep and cap proteins. When induced by an agent, the second vector may replicate to a high copy number, and thereby increased numbers of infectious adeno-associated viral particles may be generated.
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Chiorini John A.
Kotin Robert
Safer Brian
Urcelay Elena
Chambers Jasemine C.
Lillie Raymond J.
Olstein Elliot M.
Priebe Scott D.
The United States of America as represented by the Department of
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