Vector for gene transfer in liver cells

Details Vector for gene transfer in liver cells Vector for gene transfer in liver cells

1996-09-03

1999-04-20

Crouch, Deborah

Chemistry: molecular biology and microbiology

Vector, per se

514 2, 514 44, 530350, 530402, C12N 1500, A01N 3718, A01N 4304, C07K 100

Patent

active

058957596

ABSTRACT:
A tissue-specific, suitably liver specific vector for gene therapy of a diseased host, wherein a therapeutic gene is coupled to a promoter chemically, enzymatically, or over an antibody, packaged in a polypeptide coat, and coupled to a component of a preselected virus of the tissue to be treated, and when the tissue is liver tissue, then the virus is hepatitis B virus.

REFERENCES:
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Tessier, D.C., et al.; Enhanced Secretion from Insect Cells of a Foreign Protein Fused to the Honeybee Melittin Signal Peptide; Genetic Engineering Section, National Research Council of Canada, Montreal Quebec. Gene. Feb. 15, 1991; 98(2): 177-83; Bibliothek Max-Delbruck-Centrum.
Orkin et al. (referred to as NIH panel report) Report and recommendations of the panel to assess the NIH investment in research on gene therapy. Distributed by the National Institutes of Health, Bethesda, MD., Dec. 7, 1996.

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