Vector for efficient selection and/or maturation of an...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023500

Reexamination Certificate

active

08003383

ABSTRACT:
It is described a vector suitable for efficient selection and/or maturation of a recombinant antibody characterized in that it contains at least one element able to reduce the expression level and/or has an improved efficiency of display of said recombinant antibody.

REFERENCES:
patent: 3663684 (1972-05-01), Freedman et al.
patent: 1 452 599 (2004-09-01), None
patent: 1992/01047 (1992-01-01), None
patent: 1993/11236 (1993-06-01), None
patent: 01-136433 (2001-05-01), None
patent: 2005/042578 (2005-05-01), None
patent: 2005/118647 (2005-12-01), None
Scott et al. (Phage Display: A Laboratory Manual, Cold Spring Harbor Lab. Press, p. 2.1-2.19 (2001)).
Park et al. (Biochem. Biophys. Res. Commun. Aug. 28, 2000;275(2):553-7; Abstract).
O'Connell et al. (J. Molec. Biol. Aug. 2, 2002; 321(1):49-56).
Carlos F. Barbas et al. “Assembly of combinatorial antibody libraries on phage surfaces: The gene III site”, Proc Natl. Acad. Sci. USA vol. 88, pp. 7978-7982 (Sep. 1991).
J. Beekwilder et al. “A phagemid vector using the E. coli phage shock promoter facilitates phage display of toxic proteins”, GENE 228, pp. 23-31 (1999).
Elisa Beghetto et al. “Discovery of novelStreptococcus pneumoniaantigens by screening a whole genome-display library”, FEMS Microbial Lett. 262, pp. 14-21 (2006).
S. B. Brown et al. “Catalatic activity of iron (III)-centered catalysts”, Biochem J. 117, pp. 741-744 (1970).
M. A. Clark et al. “Isolation of human anti-c-erbB-2 Fabs from a lymph node-derived phage display library”, Clin. Exp. Immunol 109, pp. 166-174 (1997).
Julia A. Coronella et al. “Antigen-driven oligoclonal expansion of tumor-infiltrating B cells in infiltrating ductal carcinoma of the breast”, The Journal of Immunology 169, pp. 1829-1836 (2002).
Julia A. Coronella et al. “Evidence for an antigen-driven humoral immune response in medullary ductal breast cancer”, Cancer Research 61, pp. 7889-7899 (Nov. 1, 2001).
Julia A. Coronella-Wood et al. “Naturally occurring B-cell responses to breast cancer”, Cancer Immunol Immunother 52, pp. 715-738 (2003).
J. O. Drife et al. “Immunoglobin synthesis in the “resting” breast”, British Medical Journal 2, pp. 503-506 (1976).
Pat Edelmann et al. “Nonsense suppression context effects inEscherichia colibacteriophage T4”, Mol. Gen. Genet. 207, pp. 517-518 (1987).
Franco Felici, “Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector”, J. Mol. Bio. 222, pp. 301-310 (1991).
Sten Hammarstrom, “The carcinoembryonic antigen (CEA) family” Cancer Biology, vol. 9, pp. 67-81 (1999).
Margit H. Hansen, “Translocation of an intracellular antigen to the surface of medullary breast cancer cells early in apoptosis allows for antigen-driven antibody response elicited by tumor-infiltrating B Cells”, The Journal of Immunology 169, pp. 2701-2711 (2002).
Margit H. Hansen et al. “The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells”, PNAS vol. 98, No. 22, pp. 12659-12664 (Oct. 23, 2001).
Satoru Imahayashi et al., “Tumor infiltrating C-cell-derived IgG recognizes tumor components in human ling cancer”, Cancer Investigation 18(6), pp. 530-536 (2000).
Erik S. Kass et al., “Carcinoembryonic antigen as a target for specific antitumor immunotherapy of head and neck cancer”, Cancer Research 62, pp. 5049-5057 (Sep. 1, 2002).
Beatrix Kotlan et al., “Novel gangoslide antigen identified by B cells in human medullary breast carcinomas: The proof of principle concerning tumor infiltrating B lymphocytes”, The Journal of Immunology 175, pp. 2278-2285 (2005).
Titus Kretzschmar et al., “Evaluation of antibodies fused to minor coat protein III and major coat protein VIII of bacteriophage M13”, GENE 155, pp. 61-65 (1995).
Michael A. McGuckin et al. “Prognostic Significance of MUC1 Epithelial Mucin Expression in Breast Cancer”, Human Pathology vol. 26, No. 4 pp. 432-439 (1995).
Jeffrey H. Miller et al. “Effects of Surrounding Sequence on the Suppression of nonsense codons”, J. Mol. Bio. 164, pp. 59-71 (1983).
Philippa M. O'Brien, “Immunoglobulin genes expressed by B-lymphocytes infiltrating cervical carcinomas show evidence of antigen-driven selection”, Cancer Immunol Immunother 50, pp. 523-532 (2001).
Emilian Pavoni et al., “New display vector reduces biological bias for expression of antibodies in E. coli”, GENE 391, pp. 120-129 (2007).
Emilian Pavoni et al., “Selection, affinity maturation, and characterization of human scFv antibody against CEA protein”, BMC Cancer 6:41 (2006).
Lucien Perey et al., “Effects of differentiating agents on cell surface expression of the breast carcinoma-associated DF3-P epitope”, Cancer Research 52, pp. 6367-6370 (Nov. 15, 1992).
Alessandro Pini et al. “Design and use of a phage display library”, The Journal of Biological Chemistry, vol. 273, pp. 21769-21776 (1998).
Cornelis J. A. Punt et al. “Anti-tumor antibody produced by human tumor-infiltrating and peripheral blood B lymphocytes”, Cancer Immunol Immunother 38, pp. 225-232 (1994).
John B. B. Ridgway et al. “Identification of a human anti-CD55 Single-chin Fv by subtractive panning of a phage library using tumor and nontumor cell lines”, Cancer Research 59, pp. 2718-2723 (Jun. 1, 1999).
Rob C. Roovers et al. “Evidence for a bias toward intracellular antigens in the local humoral anti-tumor immune response of a colorectal cancer patient revealed by phage display”, Int. J. Cancer 93, pp. 832-840 (2001).
A. Rothe et al. “Construction of phage display libraries from reactive lymph nodes of breast carcinoma patients and selection for specifically binding human single chain Fv on cell lines”, International Journal of Molecular Medicine 14, pp. 729-735 (2004).
Brigitte Sanzey, “Modulation of Gene Expression by Drugs Affecting Deoxyribonucleic Acid Gyrase”, Journal of Bacteriology vol. 138, No. 1, pp. 40-47 (Apr. 1979).
Mohsen Shadid et al., “An Anti-leukemic single chain Fv antibody selected from a synthetic human phage antibody library”, Biochemical and Biophysical Research Communications 280, pp. 548-552 (2001).
K. Sikora et al. “Human hybridomas from patients with malignant disease”, Br. J. Cancer 47, pp. 135-145 (1983).
K. Sikora et al. “Human hybridomas from malignant gliomas”, The Lancet vol. 1, Issue 8262, pp. 11-14(1982).
Donald B. Smith et al. “Single-step purification of polypeptides expressed inEscherichia colias fusions with glutathione S-transferase”, GENE 67, pp. 31-40 (1988).
Herbert Soule et al. “Isolation and characterization of a spontaneously immortalized human epithelial cell line, MCF-10”, Cancer Research 50, pp. 6075-6086 (Sep. 15, 1990).
John A. Thompson et al. “Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives”, Journal of Clinical Laboratory Analysis 5, pp. 244-366 (1991).
Katherine P. Topping et al., “Isolation of human colorectal tumor reactive antibodies using phage display technology”, International Journal of Oncology 16, pp. 187-195 (2000).
Herren Wu et al., “Cloning, isolation and characterization of human tumor in situ monoclonal antibodies”, Cancer Immunol Immunother 51, pp. 79-90 (2002).
Ming-Yan Xu et al., “Production of a human signle chain-variable fragment antibody against esophageal carcinoma”, World J. Gastroenterol 10(18), pp. 2619-2623 (2004).
Manubu Yasuda et al. “Tumor-infiltrating B lymphocytes as a potential source of identifying tumor antigen in human lung cancer”, Cancer Research 62, pp. 1751-1756 (Mar. 15, 2002).
Luci

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Vector for efficient selection and/or maturation of an... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vector for efficient selection and/or maturation of an..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vector for efficient selection and/or maturation of an... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2735292

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.