Vector expressing fusion proteins and particles

Details Vector expressing fusion proteins and particles Vector expressing fusion proteins and particles

1987-04-10

1991-08-20

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Vector, per se

435 693, 435 91, 435170, 435181, 4351721, 4351723, 4352351, 4352462, 4352523, 435255, 536 27, 424 88, 935 9, 935 12, 935 22, 935 28, 935 59, 935 60, 935 47, 935 69, C12N 1579, C12N 1511, C12N 1581, A61K 3900

Patent

active

050413856

ABSTRACT:
Fusion proteins comprising a first amino acid sequence and a second amino acid sequence are disclosed. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles. The TYA gene of the yeast retrotransposon Ty codes for the first amino acid sequence. The second amino acid sequence is a biologically active antigen. The particles formed by the fusion proteins are useful in vaccines or in diagnostic or purification applications.

REFERENCES:
patent: 4722840 (1988-02-01), Valenzuela et al.
Haynes et al., 1986 (Jul.), Biotechnology 4:637-640.
Mellor et al., 1985, Nature 313:243.
Velenzuela et al., 1985, Bio/Technology 3:323-326.
Wilson et al., 1986, Nucl. Acids Res. 14: 7001-7016.

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