Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1984-01-16
1987-09-29
Hazel, Blondel
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435240, 4351723, 435320, 935 32, 935 70, C12P 2100, C12N 1500, C12N 500, C12N 100
Patent
active
046968989
ABSTRACT:
Recombinant DNA vector including (1) a promoter for a eukaryotic metalliothionein gene ligated to a gene sequence encoding hepatitis B surface antigen, and (2) at least the 69% transforming region of the bovine papilloma genome, expression of the hepatitis B surface antigen encoding gene sequence being under the control of the metallothionein promoter.
REFERENCES:
patent: 4419446 (1983-12-01), Howley et al.
patent: 4511652 (1985-04-01), Fogel et al.
Pavlakis et al 1983, "Regulation of a Metallothionein-Growth Hormone Hybrid Gene in Bovine Papilloma Virus Proc. Natl Acad Sci, v80 397-401.
Mayo et al 1982, "The Mouse Metallothionein-1 Gene is Transcriptionally Regulated by Cadmium Following Transfection into Human or Mouse Cells" Cell v29 99-108.
Burrell et al 1979, "Expression in E. Coli of Hepatitis B virus DNA Sequences Cloned in Plasmid pBR322" Nature, v279 pp. 43-47.
Hamer et al 1982, "Induction of a Mouse Metallothionein-1 Gene in Animal Virus Vectors" in Eukaryotic Viral Vectors Cold Spring Harbor Lab., pp. 7-12.
Hamer et al 1982, "Regulation In Vivo of a Cloned Mammalian Gene: Cadmium Induces the Transcription of a Mouse Metallothionein Gene . . . " J. Mol. App Gen v1, 273-288.
Fitts Renee A.
Hamer Dean H.
Hsiung Nancy
Hazel Blondel
Integrated Genetics, Inc.
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