Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1998-07-14
2000-05-09
Jones, W. Gary
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4353201, C12N 120, C12N 1563
Patent
active
060603011
ABSTRACT:
The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
REFERENCES:
patent: 5739027 (1998-04-01), Kamb
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Kamb, A.et al. (1994). "A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types," Science 264:436-440.
Nobori, T.et al. (1994). "Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers." Nature 368:753-756.
Serrano, M. et al. (1993). "A new regulatory motife in cell-cycle control causing specific inhibition of cyclin D/CDK4." Nature 366:704-707.
Sherr, C.J. (1996). "Cancer Cell Cycles." Science 274:1672-1677.
Stone, S. et al. (1995). "Complex structure and regulation of the P16(MTS1)." Cancer Research 55:2988-2994.
Jones W. Gary
Myriad Genetics Inc.
Sovaya Jehanne
LandOfFree
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