Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2006-05-17
2009-06-02
Zeman, Robert A (Department: 1645)
Chemistry: molecular biology and microbiology
Vector, per se
C435S252300, C435S456000, C435S471000, C536S023100, C424S200100
Reexamination Certificate
active
07541181
ABSTRACT:
The invention provides a nucleotide sequence representing a pathogenicity island found in species of pathogenic mycobacteria. The islands are shown as SEQ ID NOS: 3 and 4 and comprises several open reading frames encoding polypeptides. These polypeptides and their use in diagnosis and therapy form a further aspect of the invention.
REFERENCES:
patent: 5082767 (1992-01-01), Hatfield et al.
patent: 6156322 (2000-12-01), Hermon-Taylor et al.
patent: 0 288 306 (1998-10-01), None
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patent: WO 94 26312 (1994-11-01), None
patent: WO 95 01441 (1995-01-01), None
Database EMBL, Entry MT024, Accession No. U00024, Jan. 5, 1995 nt.15203-15934 100% homology with SeqID:36 nt.14306-15133 100% homology with SeqID:38 XP002033471 cited in the application.
Database EMBL, Entry MTCY277, Accession No. Z79701, Sep. 18, 1996 nt.34705-36493 100% homology with SeqID:30 nt.31972-32994 100% homology with SeqID:32 nt.33956-34687 100% homology with SeqID:34 XP002033472 cited in the application.
Database EMBL, Entry MTAD1, Accession No. AD000001, Dec. 15, 1996 nt.6775-7562 100% homology with Seq.ID:30 nt.9273-10295 100% homology with Seq.ID:32 nt.7580-8311 100% homology with Seq.ID:34 XP002033473.
Database EMBL, Entry MTCY349, Accession No. Z83018, Nov. 26, 1996 nt.34695-35426 100% homology with SeqID:36 nt.33797-34624 100% homology with SeqID:38 XP002033474.
Database EMBL, Entry MTAD9, Accession No. AD000009, Dec. 15, 1996 nt.15203-15934 100% homology with SeqID:36 nt.14306-15133 100% homology with SeqID:38 XP002033475.
Vaccine, vol. 12, No. 16, 1994, pp. 1537-1540, XP002026338 Lowrie D B et al: “Towards a DNA Vaccine Against Tuberculosis” see p. 1537-p. 1538.
Nature, vol. 351, No. 6326, Jun. 6, 1991, pp. 456-460, XP000605495 Stover C K et al: “New Use of BCG for Recombinant Vaccines” see p. 456-p. 457.
Belisle, J. T. et al, “Isolation and Expression of a Gene Cluster Responsible for Biosynthesis of the Glycopeptidolipid Antigens ofMycobacterium avium.” J. Bacteriol. 1991, 173; 6991-6997.
Belisle, J. T. et al, “Rough Morphological Variants ofMycobacterium avium.Characterisation of Genomic Deletions Resulting in the loss of Glycopeptidolipid Expression”, J. Biological Chem. 1993, 268; 10517-10523.
Mills, J.A. et al, “Loci ofMycobacterium avium ser2Gene Cluster and their Functions”, J. Bacteriol. 1994, 176:; 4803-4808.
Chemical Abstracts, vol. 74, No. 5, Feb. 1, 1971 Columbus Ohio, US; abstract No. 20614, Khachaturyan, A.A. et al: “Formation of acylases by hydrocarbon-oxidizing microorganisms” XP002190388 abstract & Biol. ZH. Arm. (1990), 23(7), 40-7.
Greenspan et al., Nature of Biotechnoogy 7:936-937, 1999.
Bowie et al, Science, 1990, 257:1306-1310.
Lehninger, Biochemistry, 1970, Worth Publishers, NY, NY.
Doran Tim
Ford John
Hermon-Taylor John
Loughlin Mark
Millar Douglas
Hermon-Taylor John
Nixon & Vanderhye P.C.
Zeman Robert A
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