Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2010-02-26
2011-12-27
Angell, J. E. (Department: 1635)
Chemistry: molecular biology and microbiology
Vector, per se
Reexamination Certificate
active
08084249
ABSTRACT:
A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.
REFERENCES:
patent: 4997913 (1991-03-01), Hallstrom et al.
patent: 5559099 (1996-09-01), Wickham et al.
patent: 5591624 (1997-01-01), Barber et al.
patent: 5824782 (1998-10-01), Holzer et al.
patent: 5856140 (1999-01-01), Chimamura et al.
patent: 5876691 (1999-03-01), Chester et al.
patent: 6143520 (2000-11-01), Marasco et al.
patent: 6277972 (2001-08-01), Afar et al.
patent: 6348584 (2002-02-01), Hodgson et al.
patent: 6514498 (2003-02-01), Antonsson et al.
patent: 6852703 (2005-02-01), Kingsman et al.
patent: 7074909 (2006-07-01), Kingsman et al.
patent: 2007/0161080 (2007-07-01), Kingsman et al.
patent: 0 336 562 (1989-10-01), None
patent: 0803574 (1997-10-01), None
patent: WO-89/07947 (1989-09-01), None
patent: WO-96/30504 (1990-05-01), None
patent: WO-92/11383 (1992-07-01), None
patent: WO-92/22653 (1992-12-01), None
patent: WO-94/11513 (1994-05-01), None
patent: WO-96/15238 (1996-05-01), None
patent: WO-96/30512 (1996-10-01), None
patent: WO-96/34969 (1996-11-01), None
patent: WO-97/17090 (1997-05-01), None
patent: WO-97/36932 (1997-10-01), None
patent: WO-98/55607 (1998-12-01), None
patent: WO-01/36486 (2001-05-01), None
Alvarez et al., “A Phase I Study of Recombinant Adenovirus Vector-Mediated Delivery of an Anti-erbB-2 Single-Chain (sFv) Antibody Gene for Previously Treated Ovarian and Extraovarian Cancer Patients,”Human Gene Therapy,8:229-242 (1997).
Anderson, F.W., “Human gene therapy,” Nature, 392:25-30 (1998).
Arafat et al., “Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv,”Gene Therapy,9:256-262 (2002).
Cameron, E., “Recent Advances in Transgenic Technology,” Mol. Bio., 7:253-265 (1997).
Chamberlain et al., “Costimmulation Enhances the Active Immunotherapy Effect of Recombinant Anticancer Vaccines,” Cancer Research, 56:2832-2836 (1996).
Chaudhary et al., “A rapid method of cloning functional variable-region antibody genes inEscherichia colias single-chain immunotoxins,” PNAS, 87:1066-1070 (1990).
Crystal, R., “Transfer of Genes to Humans: Early Lessons and Obstacles to Success,” Science, 270:404-410 (1995).
Deshane et al., “Targeted Tumor Killing via an Intracellular Antibody against erbB-2,”J. Clin. Invest.,96:2980-2989 (1995).
European Search Report for 05 02 5532, dated Jul. 10, 2006.
Forsberg et al., “Identification of Framework Residues in a Secreted Recombinant Antibody Fragment that Control Production Level and Localization inEscherichia coli,” The Jour. of Bio. Chem., 272(19):12430-12436 (1997).
Gerstmayer et al., “Costimulation of T Cell Proliferation by a Chimeric B7-2 Antibody Fusion Protein Specifically Targeted to Cells Expression the erbB2 Proto-Oncogene,”Jour. of Immun.,158:4584-4590 (1997).
Greco et al., “Cancer Gene Therapy: delivery, delivery, delivery,” Frontiers in Bioscience, 7:1516-1524 (2002).
Hammer et al., “Spontaneous Inflammatory Disease in Transgenic Rats Expressing HLA-B27 and Human β2m: An Animal Model of HLA-B27-Associated Human Disorders,” Cell, 63:1099-1112 (1990).
Houdebine, L., “Production of pharmaceutical proteins from transgenic animals,” J. Biotech, 34:269-287 (1994).
Jannot et al., “Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells,”Oncogene,13:275-282 (1996).
Kappel et al., “Regulating gene expression in transgenic animals,” Current Opinions in Biotechnology, 3:548-553 (1992).
Lamikanra et al., “In vivo evaluation of an EIAV vector for the systemic genetic delivery of therapeutic antibodies,”Gene Therapy,12:988-998 (2005).
Leong et al., “Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma,” Int. J. Cancer, 71:476-82 (1997).
Mountain, A., “Gene therapy: the first decade,” TIBTECH, 18:119-127 (2000).
Mullins et al., “Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice,” EMBO Journal, 8(13):4065-4072 (1989).
Mullins et al., “Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene,” Nature, 344:541-544 (1990).
Mullins et al., “Transgenesis in Nonmurine Species,” Hypertension, 22:630-633 (1993).
Mullins et al., “Transgenesis in the Rat and Larger Mammals,” J. Clin. Invest., 98:S37-S40 (1996).
Myers et al., “Isolation of a cDNA Encoding 5T4 Oncofetal Trophoblast Glycoprotein,” Jour. of Bio. Chem., 269(12):9319-9324 (1994).
Myers et al., Targeting immune effector molecules to human tumor cells through genetic delivery of 5T4-specific scFv fusion proteins,Cancer Gene Therapy,9:884-896 (2002).
Naldini et al., “In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector,” Science, 272:263-267 (1996).
Niemann, H., “Transgenic farm animals get off the ground,” Transgenic Research, 7:73-75 (1998).
Osaki et al., “Gene Therapy for Carcinoembryonic Antigen-producing Human Lung Cancer Cells by Cell Type-specific Expression of Herpes Simplex Virus Thymidine Kinase Gene,” Cancer Research, 54:5258-5261 (1994).
Overbeek, P., “Factors affecting transgenic animal production,” Transgenic Animal Technology, 96-98 (1994).
Promega, Catalog of Nucleic Acids, pp. 215-216 (1993/94).
Richter et al., “Clinical gene therapy in hematology: Past and future,” Int. Jour. Hematology, 73:162-169 (2001).
Riddell et al., “T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients,” Nature Medicine, 2:216-221 (1996).
Rieger et al., Glossary of Genetics and Cytogenetics, Classical and Molecular, 4th Ed., Springer-Verlag, Berlin (1976).
Rudikoff et al., “Single amino acid substitution altering antigen-binding specificity,” Proc. Natl. Acad. Sci. USA, 79:1979-1983 (1982).
Scherf et al., “Cytotoxic and Antitumor Activity of a Recombinant Tumor Necrosis Factor-B1(Fv) Fusion Protein on LeYAntigen-expressing Human Cancer Cells,”Clin. Cancer Res.,2:1523-1531 (1996).
Taurog et al., “HLA-B27 in Inbred and Non-Inbred Transgenic Mice,” Jour. of Immun., 141(11):4020-4023 (1988).
Verma et al., “Gene therapy promises, problems and prospects,” Nature, 389:239-242 (1997).
Wall, R.J., “Transgenic Livestock: Progress and Prospects for the Future,” Theriogenology, 45:57-68 (1996).
Walter et al., “Viral Vectors for Gene Transfer,” Drugs, 2:249-271 (2000).
Wels et al., “Biotechnological and gene therapeutic strategies in cancer treatment,”Gene,159:73-80 (1995).
Xiang et al., “Genetic engineering of a recombinant fusion possessing anti-tumor F(ab′)2and tumor necrosis factor,”Jour. of Bio.,53:3-12 (1997).
Bebbington Christopher Robert
Carroll Miles William
Ellard Fiona Margaret
Kingsman Susan Mary
Myers Kevin Alan
Angell J. E.
Marshall & Gerstein & Borun LLP
Oxford Biomedica (UK) Limited
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