Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-08-27
1989-10-24
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530315, A61K 3734, C07K 716
Patent
active
048762431
ABSTRACT:
Vasopressin-like peptide whose structures have been modified by an alpha-methyl amino acid at the 4 or 7 position are set forth. These compounds have potent vasopressin antagonist activities.
REFERENCES:
patent: 4469679 (1984-09-01), Huffman te al.
patent: 4481193 (1984-11-01), Ali et al.
patent: 4481194 (1984-11-01), Ali et al.
patent: 4491577 (1985-01-01), Manning et al.
patent: 4543349 (1985-09-01), Callahan et al.
Turk, John et al., "Analogues of Angiotensin II with Restricted Conformational Freedom, Including a New Antagonist", Molecular Pharmacology, vol. 12, pp. 217-224 (1976).
Turk, John et al., ".alpha.-Methyl Substrates of Carboxy-Peptidase A, Steric Probe of the Active Site"Biochemistry, vol. 14, No. 12, 1975.
Marshall, Garland, "Angiotensin II, Studies on the Biologically Active Conformation", Circulation Research II, vol. 30-31, pp. 143-150, 1972.
London, Robert E., "Testing for Cis'Proline with alpha-aminoisobutyric acid substitution", Int. J. Peptide Protein Res., 19, pp. 334-342, 1982.
Manning, Maurice et al., "Carboxy Terminus of Vasopressin Required for Activity but Not Binding", Nature, vol. 12, pp. 652 & 653.
Strasser, Frans et al., "Molecular Mechanisms of Novel Antidiuretic Antagonists Analysis of the Effects on Vasopressin Binding and Adenylate Cyclase Activation in Animal and Human Kidney", J. of Pharmacology and Experimental Therapeutics, vol.223, No. 2, pp. 50-54 (1982).
Manning, Maurice et al., "Design of more Potent Antagonists of the Antidiuretic Responses of Arginine-Vasopressin", J. Med. Chem., vol. 25, pp. 45-50 (1982).
Marshall Garland R.
Moore Michael L.
Kinzig Charles M.
Lourie Alan D.
Phillips Delbert R.
SmithKline Beckman Corporation
Williams Janice E.
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