Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Patent
1987-03-19
1988-06-07
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
530329, A61K 3702
Patent
active
047497823
ABSTRACT:
Certain vasopressin-like compounds whose structures have a .beta.,.beta.-diethyl-.beta.-mercaptopropionic acid at position 1 have unexpectedly potent V.sub.2 -antagonist activity. A species of the group is [1-.beta.,.beta.-diethyl-.beta.-mercaptopropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-8-arginine-9-desglycine]vasopressin.
REFERENCES:
Manning et al., "Design of Potent and Selective Antagonists of the Vasopressor Responses to Arginine-Vasopressin", J. Med. Chem., 1982, 25, 406-414.
Manning et al., "Synthesis and Some Pharmacological Properties of 18 Potent O-Alkyltyrosine-Substituted Antagonists of the Vasopressor Responses to Arginine-Vasopressin", J. Med. Chem., 1985, 28, 1485-1491.
Huffman William F.
Moore Michael L.
Yim Nelson C.
Lourie Alan D.
Nutter Nathan M.
Phillips Delbert R.
SmithKline Beckman Corporation
Suter Stuart R.
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