Vasonatrin peptide and analogs thereof

Details Vasonatrin peptide and analogs thereof Vasonatrin peptide and analogs thereof

1994-08-29

1996-12-10

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 530324, 530325, 530326, 530317, A61K 3816, C07K 1400, C07K 1458

Patent

active

055831087

ABSTRACT:
Synthetic analogs of C-type natriuretic peptide are provided, together with methods for their production and use as natriuretics, diuretics, and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native natriuretic peptides.

REFERENCES:
patent: 4757048 (1988-07-01), Lewicki et al.
patent: 4804650 (1989-02-01), Lewicki et al.
patent: 4935492 (1990-06-01), Lewicki et al.
patent: 5047397 (1991-09-01), Scarborough
patent: 5114923 (1992-05-01), Seilhamer et al.
patent: 5202239 (1993-04-01), Tarnowski et al.
patent: 5212286 (1993-05-01), Lewicki et al.
patent: 5434133 (1995-07-01), Tanaka et al.
FEBS, vol. 309, No. 2, Sep. 1992, pp. 185-189, Y. Shimekake et al., "The Role of the C-Terminal Region of Rat Brain Natriuretic Peptide in Receptor Selectivity".
Biochem. Biophs. Res. Commun., vol. 183, No. 3, 31 Mar. 1992, pp. 964-969, M. Furuya et al., "Structural Requirements of C-Type Natriuretic Peptide for Elevation of Cyclic GMP in Cultured Vascular Smooth Muscle Cells".
B. M. Brenner et al., "Diverse Biological Actions of Atrial Natriuretic Peptide", Physiol. Rev., 70, 665-699 (1990).
Burnett et al., "Effects of Synthetic Atrial Natriuretic Factor on Renal Function and Renin Release", Am J. Physiol., 247, F863-866 (1984).
Burnett et al., "Atrial Natriuretic Peptide Elevation in Congestive Heart Failure in the Human", Science, 231, 1145-1147 (1986).
Carpino et al., "The 9-Fluorenylmethoxycarbonyl Amino-Protecting Group", J. Org. Chem., 37, 3404-3409 (1972).
A. J. de Bold et al., "A Rapid and Potent Natriuretic Response to Intravenous Injection of Atrial Myocardial Extract in Rats", Life Sci., 28, 89-94 (1981).
T. G. Flynn et al., "The Amino Acid Sequence of an Atrial Peptide with Potent Diuretic and Natriuretic Properties", Biochem. Biophys. Res. Commun., 117, 859-865 (1981).
Hughes et al., "The Effect of Atrial Natriuretic Peptide on Human Blood Vessels", J. Hypertension, 5, S51-S53 (1987).
Y. Kambayashi et al., "Isolation and Sequence Determination of Human Brain Natriuretic Peptide in Human Atrium", FEBS Lett., 259, 341-345 (1990).
K. J. Koller et al., "Molecular Biology of the Natriuretic Peptides and Their Receptors", Circulation, 86, 1081-1088 (1992).
K. J. Koller et al., "Selective Activation of the B Natriuretic Peptide Receptor by C-Type Natriuretic Peptide (CNP)".
Meinhofer and Chang, "Solid-Phase Peptide Synthesis Using Mild Base Cleavage of N.sup.alpha -Fluorenylmethyloxycarbonylamino Acids, Exemplified by a Synthesis of Dihydrosomatostatin", Int. J. Pept. Pro. Res., 11, 246-249 (1978).
Merrifield, "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide", J. Am. Chem. Soc., 85, 2149-2154 (1963).
A. J. Stingo et al., "Cardiovascular and Renal Actions of C-Type Natriuretic Peptide", Am. J. Physiol., 262, H308-H312 (1992).
T. Sudoh et al., "C-Type Natriuretic Peptide (CNP): A New Member of Natriuretic Peptide Family Identified in Porcine Brain", Biochem. Biophys. Res. Commun., 168, 863-870 (1990).
T. Sudoh et al., "A New Natriuretic Peptide in Porcine Brain", Nature, 332, 78-81 (1988).
Y. Tawaragi et al., "Gene and Precursor Structures of Human C-Type Natriuretic Peptide", Biochem. Biophys. Res. Commun., 175, 645-651 (1991).
C. M. Wei et al., "Action of C-type Natriuretic Peptide in Isolated Canine Arteries and Veins", Am. J. Physiol., 264, H71-H73 (1993).

Affiliated with

Also associated with

Rating

Vasonatrin peptide and analogs thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vasonatrin peptide and analogs thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vasonatrin peptide and analogs thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-424195