Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1988-09-26
1991-01-01
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
435 703, 514 13, A61K 3702, C07K 710
Patent
active
049819500
ABSTRACT:
Disclosed is a vasoconstrictor peptide called Endothelin having a molecular weight of 2,500.+-.300. Endothelin contains 21 amino acid residues, wherein four cysteines form two sets of S--S bond.
In order to obtain the vasoconstrictor factors of the present invention, it is preferable to culture the endothelial cells collected from the vascular inner walls in a serum-free medium.
The vasoconstrictor peptides of the present invention can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.
REFERENCES:
patent: 4496544 (1985-01-01), Needleman
patent: 4557864 (1985-12-01), Needleman
patent: 4618600 (1986-10-01), Johnson et al.
patent: 4716147 (1987-12-01), Tjoeng et al.
Physiol., 248, C550, (1985), A. Kristine et al.
Am. J. and J. Cell. Physiol., 132, 263, (1987), (R. F. O'Brien et al.).
J. Pharmac. Exp. Ther., 236, 339, (1985), (M. N. Gillespie et al.).
I. Kifor and V. J. Dzav, Circ. Res., 60, 442, (1987).
M. Yanagawawa et al., Abstract, C-5, 77th Japan Pharmacological Meeting.
K. Takemoto, 79, 5485-5489, (1982).
C. Minth et al., Proc. Natl. Acad. Sci., (U.S.A.), 81, 4577-4581, (1984).
K. A. Hickey et al., Am. J. Physiol., 248:C550-C556, (1985).
R. F. O'Brien et al., J. Cell Physiol., 132, 263-270, (1987).
M. N. Gillespie et al., J. Pharmacology and Experimental Therapeutics, 236, 339-343, (1986).
K. Kifor and V. J. Dzau, Circulation Research, 60, 422-428, (1987).
M. Yanagisawa et al., Nature, 332, 411-415.
Y. Itoh et al., FEBS Letters, 231(2), 440-444, (1988).
Goto Katsutoshi
Kimura Sadao
Kurihara Hiroki
Masaki Tomoh
Mitsui Youji
Conlin David G.
Corless Peter F.
Director--General of Agency of Industrial Science and Technology
Lee Lester L.
Takeda Chemical Ind. Ltd.
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