Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-06-02
1998-09-01
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142275, 5142305, 514311, 514634, 544105, 544402, 546178, 546246, 548217, 548491, 548503, 548569, 549 15, 549362, 549400, 549401, 549408, 549462, 549366, 564104, 564230, 564240, 564241, A61K 31155, C07C27930, C07D23914, C07D23942
Patent
active
058011790
ABSTRACT:
The present invention is concerned with compounds having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R.sup.1 is hydrogen or C.sub.1--6 alkyl; R.sup.2 is hydrogen or C.sub.1- 6 alkyl; R.sup.3 is C.sub.1-6 alkyl, hydroxy, cyano, halo, C.sub.1-6 alkyloxy, aryloxy, arylmethoxy, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 alkyl--S--, C.sub.1-6 alkyl(S.dbd.O)--, C.sub.1-6 alkylcarbonyl; R.sup.4 is hydrogen, halo, hydroxy, C.sub.1-6 alkyl, or C.sub.1-6 alkyloxy; or R.sup.3 and R.sup.4 taken together form a bivalent radical; R.sup.5 and R.sup.6 each independently are hydrogen, halo, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, aryloxy or arylmethoxy; R.sup.7 is hydrogen; Alk.sup.1 is C.sub.2-5 alkanediyl; Alk.sup.2 is C.sub.2-15 alkanediyl; Q is a heterocyclic ring containing at least one nitrogen atom or a radical of formula ##STR2## Pharmaceutical compositions, preparations and use as a medicine are described.
REFERENCES:
patent: 4438128 (1984-03-01), Wiedemann et al.
patent: 4593039 (1986-06-01), Baldwin et al.
patent: 5229392 (1993-07-01), George et al.
patent: 5399581 (1995-03-01), Laragh
patent: 5548061 (1996-08-01), Masaki et al.
O'Connor, Adrenal Medulla, Cecil Textbook of Medicine, 20th Edition, vol. 2, pp. 1253-1257, 1996.
Posner, Disorders of Sensation, Cecil Textbook of Medicine, 20th Edition, vol. 2, pp. 2030-2032, 1996.
Benkert et al., Relations between structure and the nonadrenaline depleting effects of guanidine and amidine derivatives, Arzneim. Forsch., 25(9), pp. 1404-1408, 1975.
Benkert et al., Arzneimittel Forschung. Drug Research, vol. 25, No. 9, 1975, pp. 1404-1408.
De Bruyn Marcel Frans Leopold
Van Lommen Guy Rosalia Eugene
Wigerinck Piet Tom Bert Paul
Ciambrone Coletti Ellen
Janssen Pharmaceutica NV
Rao Deepak R.
Shah Mukund J.
LandOfFree
Vasoconstrictive substituted aryloxyalkyl diamines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vasoconstrictive substituted aryloxyalkyl diamines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vasoconstrictive substituted aryloxyalkyl diamines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-270530