Vasoactive lung polypeptides

Details Vasoactive lung polypeptides Vasoactive lung polypeptides

1976-01-19

1978-09-12

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 2601125R, B66F 104, A61K 3700, C07C10352

Patent

active

041137116

ABSTRACT:
Vasoactive polypeptide fractions having biological activity isolated in purified form from animal lungs induce peripheral vasodilation and systemic hypotension. One of the peptides exhibits the property of relaxing isolated non-vascular smooth muscle organs while the other peptide contracted these tissues. The peptide fractions are obtained from the lungs of animals by procedures involving boiling and mincing the lung, extracting the peptides into acetic acid, adsorbing by alginic acid, eluting with HCl and salting out, extracting into alcohol, again adsorbed with alginic acid, fractionating by gel chromatography, e.g. on Sephadex G-25, and by ion exchange chromatography, e.g. on carboxymethyl cellulose, followed by further ion exchange chromatography and, optionally, countercurrent distribution.

REFERENCES:
patent: 3862927 (1975-01-01), Said et al.
patent: 3879371 (1975-04-01), Said et al.
patent: 3880826 (1975-04-01), Said et al.
patent: 3898329 (1975-04-01), Said et al.
Said et al.: Nature: 224, 699-700 (1969).
Said et al.: Science, 169, 1217-1218 (1970).

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