Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1987-02-26
1989-05-30
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C07K 710
Patent
active
048352527
ABSTRACT:
Novel biologically active vasoactive intestinal peptide (VIP) analogues are provided.
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Bodanszky and Natarajan, "Synthesis and Some Pharmacological Properties of the 23-Peptide 15-Lysine-Secretin-(5-27). Special Role of the Residue in Position 15 in Biological Activity of the Vasoactive Intestinal Polypeptide," Journal of Medicinal Chemistry 21, No. 11, 1171-1173 (1978).
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Turner et al., "A Fragment of Vasoactive Intestinal Peptide, VIP (10-28), is an Antagonist of VIP in the Colon Carcinoma Cell Line, HT29," Peptides 7, 849-854 (1986).
James B. D. Palmer et al., "VIP and PHM and Their Role in Nonadrenergic inhibitory Responses in Isolated Airways," Am. Physiol. Soc., pp. 1322-1328, 1986.
Patrick Robberecht et al., "[D-Phe.sup.4 ] Peptide Histidine-Isoleucinamide ([D-Phe.sup.4 ]PHI), a Highly Selective Vasoactive-Intestinal-Peptide (VIP) Agonist, Discriminates VIP-Preferring From Secretin-Preferring Receptors in Rat Pancreatic Membranes," Eur. J. Biochem., 165: 242-249 (1987).
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R. Dimaline et al., "A Novel Family of VIP-Like Peptides From the Dogfish Scyliorhinus Canicula," Reg. Peptides, 18: 356, 1987.
Kaiser Emil T.
Musso Gary F.
Chan Christina
Phillips Delbert R.
The Salk Institute Biotechnology Industrial Associates, Inc.
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