Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-03-12
2000-10-31
Jones, Dwayne C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424 944, 424718, A01N 4304
Patent
active
061403091
ABSTRACT:
A method is disclosed for treating and preventing diseases, wherein at least one of the causes of the disease is .beta.-amyloid peptide induced change in free radical production resulting in vascular endothelial dysfunction and vasoactivity, by antagonizing vascular free radicals in excess of functional equilibrium.
REFERENCES:
patent: 4439196 (1984-03-01), Higuchi
patent: 4447224 (1984-05-01), DeCant, Jr. et al.
patent: 4447233 (1984-05-01), Mayfield
patent: 4475196 (1984-10-01), La Zor
patent: 4486194 (1984-12-01), Ferrara
patent: 4487603 (1984-12-01), Harris
patent: 4736866 (1988-04-01), Leder et al.
patent: 5175383 (1992-12-01), Leder et al.
patent: 5175384 (1992-12-01), Krimpenfort et al.
patent: 5175385 (1992-12-01), Wagner et al.
patent: 5221778 (1993-06-01), Byrne et al.
patent: 5288846 (1994-02-01), Quertermous et al.
patent: 5298422 (1994-03-01), Schwartz et al.
patent: 5347075 (1994-09-01), Sorge
patent: 5360735 (1994-11-01), Weinshank et al.
patent: 5387742 (1995-02-01), Cordell
Beckman et al., "ALS, SOD and peroxynitrite" Nature, 364:584 (1993).
Bennett et al., "Evidence That the APOE Locus Influences Rate of Disease Progression in late Onset Familial Alzheimer's Disease . . . " Amer. J. of Medical Genetics (Neuropsychiatric Genetics), 60:1-6 (1995).
Betz et al., Basic Neurochem. Molecular Cell, (Raven Press Ltd., NY) 5th Ed., pp. 681-699 (1994.
Blennow et al., "White-matter lesions on CT in Alzheimer patients: relations to clinical . . . ", Acta Neurologica Scandinavica 83 (3):187-93.
Buee et al., "Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders" Acta Neuropathol 87:469-480 (1994).
Bulkley G.B. Free Radicals and other reactive oxygen metabolites: Clinical relevance and the therapeutic efficacy of antioxidant therapy Surgery vol. 113, No. 5, pp. 479-484 (1993).
Burke et al., "Blood pressure regulation in Alzheimer'disease" Journal of the Autonomic Nervous System 48 (1) pp. 65-71 (1994).
Burke and Olson, "Preparation of Clone Libraries in Yeast Artificial-Chromosome Vectors" Methods in Enzymology, vol. 194, "Guide to Yeast Genetics and Molecular Biology" Chap. 17, pp. 251-270 (1991).
Byung Pal Yu, "Cellular Defenses against damage from reactive oxygen species" Physiological Reviews vol. 74, No. 1, pp. 139-162 (1994).
Capecchi, "Altering the Genome by Homologous Recombinations" Science vol. 244 pp. 1288-1292 (1989).
Corder et al., "Gene Dose of Apolipoprotein E type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families" Science vol. 261, pp. 921-923 (1993).
Davies et al., "Targeted alterations in yeast artificial chromosomes for inter-species gene transfer" Nucleic Acids Research, vol. 20, No. 11, pp. 2693-2698 (1992).
Davignon et al., "Apolipoprotein E Polymorphism and Atherosclerosis" Arterlosclerosis 8:1-21, (1988).
Dickinson et al., "High frequency gene targeting using insertional vectors" Human Molecular Genetics, vol. 2, No. 8 pp. 1299-1302 (1993).
Elmstahl et al., "Autonomic cardiovascular reponses to tilting in patients with Alzheimer's disease and in healthy elderly women" Age and Aging. 21 4): 301-7 (1992).
Etcheberrigaray et al., Soluble .beta.-Amyloid Induction of Alzheimer's Phenotype for Human Fibroblast K.sup.+ Channels Science 264:276-279 (1994).
Furchgott and Zawadzki, "The Obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine" Nature, vol. 288:373-376 (1980).
Furchgott et al., Jap. J. Pharmacol. 58: Suppl. 2, pp. 185-191 (1992).
Gilligan et al., "Acute Vascular Effects of Estrogen in Postmenopausal women" Circulation vol. 90, No. 2, pp. 786-791 (1994).
Gimbrone et al., "Vascular Endothelium: An Integrator of Pathophysiological Stimuli in Atherogenesis" Ann. New York Acad. of Science 148:122-131 (1995).
Glenner and Wong, "Alzheimer's Disease: Initial report of the purification and characterization of a novel cerebrovascular . . . " Biochem. Biophys. Res. Commun., vol. 120, No. 3, pp. 855-890 (1984).
Greenberg et al., "Apolipoprotein E .epsilon.4 and Cerebral Hemorrhage Associated with Amyloid Angiopathy" Annals of Neurology, vol. 38,. No. 2, pp. 254-259 (1995).
Edward D. Hall, "Lipid Antioxidants in Acute Central Nervous System Injury" Annals of Emergency Medicine, 22:1022-1027 (1993).
Harmon, "Free Radical theory of Aging: A hypothesis on pathogenesis of senile dementia of the alzheimer's type" Age, vol. 16, pp. 23-30 (1993).
Huxley et al., "The human HPRT Gene on a Yeast Artificial Chromosome Is Functional When Transferred to Mouse Cells by Cell Fusion", Genomics, 9:742-750 (1991).
Hyman et al., "Nitric Oxide Synthase-Containing Neurons in the Hippocarnpal Formation in Alzheimer's Disease" Ann. Neurol. 32:818-820 (1992).
Jakobovits et al., "Germ-line transmission and expression of a human-derived yeast artificial chromosome", Nature, vol. 362, pp. 255-261 (1993).
Katusic and Vanhoutte, "Superoxide anion is an endothelium-derived contracting factor" Am. J. Physiol. 257:H33-7 (1989).
Kontos et al., "Oxygen radicals mediate the cerebral arteriolar dilation from arachidonate and bradykinin in cats" Circ. Res. 55:295-303 (1984).
Kureja et al., "PGH Synthase and Lipoxygenase Generate Superoxide in the presence of NADH or NADPH" Circulation Research, vol. 59, No. 6 pp. 612-619 (1986).
Lamb et al., "Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice" Nature Genetics, vol. 5, pp. 22-29 (1993).
Lipton et al., "A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds" Nature, vol. 364, pp. 626-632 (1993).
Mandybur T.I., "The Incidence of cerebral amyloid angiopathy in alzheimer's disease" Neurology, 25:120-126 (1975).
Marshall et al., "Independent blockade of cerebral vasodilation from acetylcholine and nitric oxide" Am. J. Physiol. 255:H847-54 (1988).
Mattson et al., ".beta.-Amyloid precursor protein metabolites and loss of neuronal Ca.sup.2+ hmeostasis in alzheimer's disease" TINS 16:409-414 (1993).
Matt-Schieman M. et al., "Hereditary cerebral hemorrhage with amyloidisis (Dutch): a model for congrophilic plaque . . . " Acta Neuropathologica 88(4):371-8 (1994).
Moncada et al., "Endothelium-derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet function" Biochem. Pharmacol. 37:2494-2501 (1988).
Nathan et al., "Differential Effects of Apolipoproteins E3 and E4 on neuronal growth in vitro" Science, vol. 264:850-852 (1994).
Olanow, C.W., "A radical hypothesis for neurodegeneration", TINS, 16:439-444 (1993).
Pardridge, "Blood-brain barrier and new approaches to brain drug delivery", The Western Journal of Medicine 156(3) pp. 281-286 (1992).
Pardridge, "Recent Development in Peptide Drug Delivery to the brain" Pharmacology & toxicology, 71(1) pp. 3-10 (1992).
Pardridge et al., Proc. Natl. Acad. Sci. USA 90(7) 2618-2622 (1993).
Pomara et al., "Pretreatment postural blood pressure drop as a possible predictor of response to the cholinesterease inhibitor . . . " Psychopharmacology Bulletin 27 (3) pp. 301-307 (1991).
Pou et al., "Generation of superoxide by purified brain nitric oxide synthase" Journal of Biological Chemistry, vol. 267, No. 34, pp. 24173-24176 (1992).
Price et al., "Toxicity of synthetic A.beta. peptides and modeling of alzheimer's disease" Neurobiology of Aging, vol. 13, pp. 623-625 (1992).
Rosenblum, "Effects of free radical generation on mouse pial arterioles: probable role of hydroxyl radicals" Am. J. Physiol., 245:H 139-42 (1983).
Rosenblum, "Hydroxyl radical mediates the Endothelium-dependent Relaxation Produced by Bradykinin in Mouse Cerebral Arterioles" Circulation Research, vol. 61, No. 4 pp. 601-603 (1987).
Rossor, et al., "Alzheimer's disease families with amyloid precursor protein mutations" Annals of the New York Academy of Sciences, 24:695:198-202 (1993).
Rothstein, Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast, Methods in Enzymology, vol. 194, pp. 281-301 (1991).
Saunders, a. et al., "Association o
Mullan Michael
Thomas Thomas N.
Jones Dwayne C.
University of South Florida
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