Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-11-12
2000-01-04
Jones, Dwayne C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424718, 424 944, A01N 4304
Patent
active
060110198
ABSTRACT:
A method is disclosed for treating and preventing diseases, wherein at least one of the causes of the disease is .beta.-amyloid peptide induced change in free radical production resulting in vascular endothelial dysfunction and vasoactivity, by antagonizing vascular free radicals in excess of functional equilibrium. An animal model for the disease is also disclosed.
REFERENCES:
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Subramaniam, R. et al., "Beta-Amyloid (32-35) toxicity to biomolecules: implications to Alzheimer's disease.", Alzheimer's Res. 1(3), pp. 141-144, 1995, see abstract.
Butterfeild, D. et al., "Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons.", Exp. Neurol., 132(2), pp. 193-202, 1995, (see abstract).
Behl, C. et al., "Hydrogen peroxide mediates amyloid beta protein toxicity.", Cell 77(6), pp. 817-827, 1994.
Byung Pal Yu, "Cellular Defenses against damage from reactive oxygen species", Physiological Reviews, vol. 74, No. 1, pp. 139-162, 1994.
De Jonge et al., Nimodipine: Cognition, Aging, and Degeneration. Clin. Neuropharmacol., (1993) 16/Suppl. 1 (S25-S30).
Arendash Gary W.
Crawford Fiona C.
Mullan Michael
Suo Zhiming
Thomas Thomas N.
Jones Dwayne C.
University of South Florida
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