Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone
Patent
1985-06-20
1988-01-12
Apley, Richard J.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
Bone
623 1, 623 66, 427 2, 4272556, 427296, 427 41, 427 40, 128334R, 204169, 428395, 428421, A61F 204, A61F 206
Patent
active
047189070
ABSTRACT:
Disclosed is a method of producing implantable prosthetic devices, e.g., tubular vascular prostheses having a substantially non-thrombogenic inside surface and a biocompatible outside surface. The method involves deposition onto an elongate substrate, e.g., a porous tubular substrate, of a fluorine-containing coating by inducing glow discharge progressively along the length of a tubular reaction vessel. A polymerizable fluorine-containing gas is flowed through the tubular substrate and a portion of the gas migrates radially to traverse the pores of the substrate. An RF field is applied to successive volumes of the gas within the vessel and tube. A substantially non-thrombogenic fluorinated coating with a first fluorine to carbon ratio deposits and bonds to the inside surface of the substrate, and a fluorinated biocompatible cross-linked coating with a lower F/C atomic ratio than the inside coating deposits and bonds to the outside surface of the substrate. The method of the invention can produce uniform coatings containing fluorine over the surface of elongated substrates. The coatings can be engineered to have a very low surface energy and to be essentially non-thrombogenic.
REFERENCES:
patent: 3068510 (1962-12-01), Coleman
patent: 3663265 (1972-05-01), Lee et al.
patent: 3839743 (1974-10-01), Schwarcz
patent: 4076916 (1978-02-01), Lagow
patent: 4188426 (1980-02-01), Auerbach
patent: 4193138 (1980-03-01), Okita
patent: 4229838 (1980-10-01), Mano
patent: 4252848 (1981-02-01), Datt et al.
patent: 4264750 (1981-04-01), Anand et al.
patent: 4286341 (1981-09-01), Greer et al.
patent: 4349582 (1982-09-01), Beerwald et al.
patent: 4404256 (1983-09-01), Anand et al.
patent: 4488954 (1984-12-01), Hatada et al.
patent: 4632842 (1986-12-01), Karwoski et al.
patent: 4652263 (1987-03-01), Herweck et al.
patent: 4656083 (1987-04-01), Hoffman et al.
Garfinkle, Hoffman, Ratner, Reynolds, & Hanson-"Effects of a Tetrafluoroethylene Glow Discharge on Patency of Small Diameter Dacron Vascular Grafts", vol. XXX Trans Am. Soc. Artif. Intern Organs, 1984--pp. 432-440.
Yasuda, H.-"Glow Discharge Polymerization", vol. 16, Journal of Polymer Science: Macromolecular Reviews, pp. 199-293, 1981.
Yasuda & Hirotsu-"Critical Evaluation of Conditions of Plasma Polymerization" Materials Research Center, University of Missouri-Rolla, Rolla, Missouri 1977.
Yasuda & Hsu, "Some Aspects of Plasma Polymerization of Fluorine-Containing Organic Compounds. II. Comparison of Ethylene and Tetrafluoroethylene", vol. 16, Journal of Polymer Sci., 415-425 (1978).
Soong & Bell--"The Effects of Hydrogen on the Plasma Polymerization of Tetrafluoroethylene", vol. 21, Polymer Engineering & Science, Aug., No. 11 (1981).
Morosoff & Yasuda-"Plasma Polymerization of Tetrafluoroethylene II. Capacitive Radio Frequency Discharge", vol. 23, Journal of Applied Polymer Science, pp. 3449-3470, (1979).
Masuoka & Yasuda-"Plasma Polymerization of Tetrafluoroethylene III. Reproducibility and Effects of Substrate and Reactor Materials", vol. 19, Journal of Polymer Sci., pp. 2937-2946 (1981).
Morosoff & Yasuda--"Plasma Polymerization of Tetrafluoroethylene III. Capacitive Audio Frequency (10 kHz) & AC Discharge", vol. 23, Journal of Applied Polymer Sci., pp. 3471-3488, (1979).
Yanagihara & Yasuda, "Plasma Polymerization of Tetrafluoroethylene IV. Comparison of Ethylene & Tetrafluoroethylene by Measurement of Electron Temperature & Density of Positive Ions", vol. 20, Journ. of Polymer Sci., pp. 1833-1846, (1982).
Yasuda & Gazicki, "Biomedical Applications of Plasma Polymerization & Plasma Treatment of Polymer Surfaces, vol. 3, Biomaterials--pp. 68-77, Apr. (1982).
Cohen & Baddour--"Surface Modification of Low Density Polyethylene in a Fluorine Gas Plasma", vol. 22, Polymer, pp. 361-371, Mar. (1981).
Corbin, Cohen & Baddour--"Kinetics of Polymer Surface Fluorination: Elemental and Plasma-Enhanced Rreactions", vol. 23, Polymer, pp. 1546-1548, Sep. (1982).
Yasuda & Hirotsu--"Distribution of Polymer Deposition in Plasma Polymerization II. Effect of Reactor Design", vol. 16, Journal of Polymer Science: Polymer Chemistry Edition, pp. 313-326, (1978).
Yasuda--"Glow Discharge Polymerization", vol. 3, pp. 102-122, Contemporary Topics in Polymer Science, (1979).
Yasuda et al. "Glow Discharge Polymers as Coatings for Implanted Devices", pp. 109-113 ISA (1981).
Matsuzawa & Yasuda, "Semi-Continuous Plasma Polymerization Coating Onto the Inside Surface of Plastic Tubing", pp. 2-21.
Dept. of Chemical Engineering & Graduate Center for Materials Research University of Missouri-Rolla, Rolla, MO 65401.
Garfinkle et al. "Improved Patency in Small Diameter Dacron Vascular Grafts after a Tetrafluoroethylene Glow Discharge Treatment", p. 337, Second World Congress on Biomaterials, 10th Ann. Mtg., Apr. 27-May 1 (1984).
Ratner et al, "RF Plasma-Deposited Films as Model Substrates for Studying Biointeractions", p. 189, Second World Congress on Biomaterials, 10th Ann Mtg. Apr. 27-May 1, 1984.
Yasuda et al, "Blood Surface Interaction Investigated with Ultrathin Coatings of Glow Discharge Polymers Applied onto the Inner Surface of Small Diameter Silastic Tubing"-Second World Congress on Biomaterials, 10th Ann Mtg., Apr. 27-May 1, 1984.
Hoffman, Garfinkle, Ratner, "Surface Modification of Small Diameter Dacron Vascular Grafts After a Tetrafluoroethylene Glow Discharge Treatment"-Second World Congress on Biomaterials-10th Annual Mtg., Apr. 27-May 1, 1984.
Dr. Hirotsugu K. Yasuda Abstract, "Method and Design of Equipment to Coat Inside Surface of Long Plastic Tubing, Univ. of Missouri.
Karwoski Theodore
Matsuzawa Yasuo
Apley Richard J.
Atrium Medical Corporation
Cannon Alan W.
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