Vascular permeability factor targeted compounds

Details Vascular permeability factor targeted compounds Vascular permeability factor targeted compounds

1994-10-24

1997-08-19

Jacobson, Dian C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

5303871, 5303877, 5303879, 530402, C07K 14675, C07K 1451, C07K 1618, C07K 1626

Patent

active

056590130

ABSTRACT:
New compounds that bind specifically to vascular permeability factor (VPF) are used in methods of targeting these compounds, which include effector molecules that are, e.g., toxic, radioactive, or serve as marker labels, for tumor cells and the associated blood vessel endothelial cells, based on the discovery that VPF concentrates selectively in the endothelium and basement membrane lining tumor-associated blood vessels to a far greater degree than in normal vessels. By targeting VPF rather than the tumor cells themselves, the invention avoids the problems of tumor heterogeneity and diffusion distance.

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