Vascular endothelial growth factor (VEGF) nucleic acid ligand co

Details Vascular endothelial growth factor (VEGF) nucleic acid ligand co Vascular endothelial growth factor (VEGF) nucleic acid ligand co

1997-07-21

2000-04-18

Zitomer, Stephanie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 514 44, 935 77, 935 78, C07H 2102, C07H 2104, C12Q 168, A61K 3170

Patent

active

060516984

ABSTRACT:
This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.

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Jaschke et al., "Synthesis and properties of oligodeoxyribonucleotide-polyethylene glycol conjugates," Nuc. Acids Res. 22(22):4810-4817, 1994.
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Shea et al., "Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates," Nuc. Acids Res. 18(13):3777-3483, 1990.

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