Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-02-05
2000-10-10
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
530350, 530399, 4353201, 435325, 536 2351, 514 2, 514 12, C07K 14475, C12N 1518
Patent
active
061300713
ABSTRACT:
Provided are purified and isolated VEGF-C cysteine deletion variants that bind to Flt4 receptor tyrosine kinase (VEGFR-3) but demonstrate reduced binding (relative to VEGF-C) to kdr receptor tyrosine kinase (VEGFR-2); polynucleotides encoding the polypeptide; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the foregoing.
REFERENCES:
patent: 4959314 (1990-09-01), Mark et al.
patent: 5219739 (1993-06-01), Tischer et al.
patent: 5326695 (1994-07-01), Andersson et al.
patent: 5332671 (1994-07-01), Ferrara et al.
patent: 5607918 (1997-03-01), Eriksson et al.
patent: 5932540 (1999-08-01), Hu et al.
patent: 5935820 (1999-08-01), Hu et al.
Alitalo et al., "Vascular Endothelial Growth Factors and Receptors Involved in Angiogenesis," The 9th International conference of the International Society of Differentiation (ISD), Development, Cell Differentiation and Cancer, Pisa (Italy), Sep. 28-Oct. 2, 1996, p. 66 (Abstract S22).
Alitalo et al., "Vascular Endothelial Growth Factors B and C and Receptors Involved in Angiogenesis," German-American Academic Council Foundation (GAAC)/Stiftung Deutsch-Amerikanisches Akademisches Konzil (DAAK), 2nd Symposium on Current Problems in Molecular Medicine: The Role of Cytokines in Human Disease, Nov. 17-20, 1996, Ringberg Castle, Germany, p. 1 (Abstract).
Andersson et al., "Assignment of Interchain Disulfide Bonds in Platelet-Derived Growth Factor (PDGF) and Evidence for Agonist Activity of Monomeric PDGF," J. Biol. Chem., 267(16):11260-11266 (Jun. 5, 1992).
Aprelikova et al., "FLT4, A Novel Class III Receptor Tyrosine Kinase in Chromosome 5q33-qter," Cancer Research, 52:746-748 (Feb. 1, 1992).
Auffray et al., H. sapiens partial cDNA sequence; clone c-1wf11. EST-STS Accession No. Z44272 (Nov. 6, 1994).
Ausprunk, et al., "Migration and Proliferation of Endothlial Cells in Preformed and Newly Formed Blood Vessels during Tumor Angiogenesis," Microvasc. Res., 14:53-65 (1977).
Basilico et al., "The FGF Family of Growth Factors and Oncogenes," Adv. Cancer Res., 59:145-165 (1992).
Berse et al., "Vascular Permeability Factor (Vascular Endothlial Growth Factor) Gene is Expressed Differentially in Normal Tissues, Macrophages, and Tumors," Mol. Biol. Cell., 3:211-220 (Feb., 1992).
Betsholtz et al., "cDNA Sequence and Chromosomal Localization of Human Platelet-Derived Growth Factor A-Chain and Its Expression in Tumor Cell Lines," Nature, 320:695-699 (Apr., 1986).
Borg et al., "Biochemical Characterization of Two Isoforms of FLT4, a VEGF Receptor-Related Tyrosine Kinase," Oncogene, 10:973-84 (1995).
Breier et al., "Expression of Vascular Endothelial Growth Factor During Embryonic Angiogenesis and Endothelial Cell Differentiation," Development, 114:521-532 (1992).
Cao et al., "Heterodimers of Placenta Growth Factor/Vascular Endothelial Growth Factor," J. Biol. Chem., 271(6):3154-3162 (Feb. 9, 1996).
Capecchi, M.R., "Altering the Genome by Homologous Recombination," Science, 244:1288-1292 (Jun. 16, 1989).
Chen and Shyu, "Selective Degradation of Early-Response-Gene mRNAs: Functional Analyses of Sequence Features of the AU-Rich Elements," Mol. Cell Biol., 14(12):8471-8482 (Dec., 1994).
Cheng and Flanagan, "Identification and Cloning of ELF-1, A Developmentally Expressed Ligand for the Mek4 and Sek Receptor Tyrosine Kinases," Cell, 79:157-168 (Oct. 7, 1994).
Claesson-Welsh et al., "Identification and Structural Analysis of the A Type Receptor for Platelet-derived Growth Factor," J. Biol. Chem., 264(3):1742-1747 (Jan. 25, 1989).
Claesson-Welsh et al., "cDNA Cloning and Expression of the Human A-type Platelet-Derived Growth Factor (PDGF) Receptor Establishes Structural Similarity to the B-type PDGF Receptor," Proc. Nat'l Acad. Sci., USA, 86(13):4917-4921 (Jul., 1989).
Claesson-Welsh et al., "cDNA Cloning and Expression of a Human Platelet-Derived Growth Factor (PDGF) Receptor Specific for B-Chain-Containing PDGF Molecules," Mol. Cell Biol., 8(8):3476-3486 (Aug., 1988).
Coffin et al., "Angioblast Differentiation and Morphogenesis of the Vascular Endothelium in the Mouse Embryo," Devel. Biol., 148:51-62 (1991).
Collins et al., "Cultured Human Endothelial Cells Express Platelet-Derived Growth Factor B Chain: cDNA Cloning and Structural Analysis," Nature, 316:748-750 (Aug., 1985).
Curran and Franza, "Fos and Jun: The AP-1 Connection," Cell, 55:395-397 (Nov. 4, 1988).
De Vries et al., "The fms-Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor," Science, 255:989-991 (Feb. 21, 1992).
Dignam et al., "Balbiani Ring 3 in Chironomus tentans Encodes a 185-kDa Secretory Protein Which is Synthesized Throughout the Fourth Larval Instar," Gene, 88:133-140 (1990).
DiSalvo et al., "Purification and Characterization of a Naturally Occurring Vascular Endothelial Growth Factor: Placenta Growth Factor Heterodimer," J. Biol. Chem., 270(13):7717-7723 (Mar. 31, 1995).
Don et al., "`Touchdown` PCR to Circumvent Spurious Priming During Gene Amplification," Nucl. Acids Res., 19:4008 (1991).
Dumont et al., "Dominant-negative and Targeted Null Mutations in the Endothelial Receptor Tyrosine Kinase, tek, Reveal a Critical Role in Vasculogenesis of the Embryo," Genes Dev., 8:1897-1909 (1994).
Dumont et al., "Vascularization of the Mouse Embryo: A Study of flk-1, tek, tie and Vascular Endothelial Growth Factor Expression During Development," Development Dynamics, 203:80-92 (1995).
Dvorak et al., "Review: Vascular Permeability Factor/Vascular Endothelial Growth Factor, Microvascular Hyperpermeability, and Angiogenesis," Amer. J. Path., 146:1029-1039 (1995).
Eichmann et al., "Two Molecules Related to the VEGF Receptor are Expressed in Early Endothelial Cells During Avian Embryonic Development," Mech. Dev., 42:33-48 (1993).
Ferrara et al., "Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins," Endocrine Rev., 13(1):18-32 (1992).
Finnerty et al., "Molecular Cloning of Murine FLT and FLT4," Oncogene, 8(11):2293-2298 (1993).
Flamme et al., "Vascular Endothelial Growth Factor (VEGF) and VEGF-Receptor 2 (flk-1) are Expressed During Vasculogenesis and Vascular Differentiation in the Quail Embryo," Devel. Biol., 169:699-712 (1995).
Flanagan and Leder, "The kit Ligand: A Cell Surface Molecule Altered in Steel Mutant Fibroblasts," Cell, 63:185-194 (Oct. 5, 1990).
Folkman, "Angiogenesis in Cancer, Vascular, Rheumatoid and Other Disease," Nature Med., 1(1):27-31 (1995).
Folkman et al., "Angiogenesis," J. Biol. Chem., 267(16):10931-10934 (Jun. 5, 1992).
Folkman et al., "Long-term Culture of Capillary Endothelial Cells," Proc. Nat'l Acad. Sci., USA, 76(10):5217-5221 (Oct., 1979).
Fong et al., "Role of the Flt-1 Receptor Tyrosine Kinase in Regulating the Assembly of Vascular Endothelium," Nature, 376:66-70 (Jul. 6, 1995).
Fossum et al., "Lymphedema Etiopathogenesis," J. Vet. Int. Med., 6:283-293 (1992).
Fournier et al., "Mutation of Tyrosine Residue 1337 Abrogates Ligand-Dependent Transforming Capacity of the FLT4 Receptor," Oncogene, 11(5):921-931 (Sep. 7, 1995).
Friesel et al., "Molecular Mechanisms of Angiogenesis: Fibroblast Growth Factor Signal Transduction," FASEB J., 9:919-25 (1995).
Fukumura et al., "Tumor Necrosis Factor .alpha.-induced Leukocyte Adhesion in Normal and Tumor Vessels: Effect of Tumor Type, Transplantation Site, and Host Strain," Cancer Research, 55:4824-4829 (Nov. 1, 1995).
Galland et al., "The Flt4 Gene Encodes a Transmembrane Tyrosine Kinase Related to the Vascular Endothelial Growth Factor Receptor," Oncogene, 8:1233-1240 (1993).
Genbank M22734, "Human Platelet-derived Growth Factor A Type Receptor mRNA, Complete cds.," Deposited by Claesson-Welsh et al., Dated Jan. 7, 1995.
Genbank M21616, "Human Platelet-derived Growth Factor (PDGF) Receptor mRNA, Complete cds." Deposited by Claesson-Welsh et al., Dated Sep. 28, 1992.
Genbank M32977, "Human Heparin-binding Vascular Endothelial Growth Factor (VEGF) mRNA, Complete cds." Deposited by Leung et al., Dated Feb. 28, 1991.
Genbank S66407, "FLT4 Receptor Tyrosine Kinas
Alitalo Kari
Joukov Vladimir
Helsinki University Licensing Ltd.
O'Hara Eileen B.
Ulm John
LandOfFree
Vascular endothelial growth factor C (VEGF-C) .DELTA.Cys.sub.156 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vascular endothelial growth factor C (VEGF-C) .DELTA.Cys.sub.156, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vascular endothelial growth factor C (VEGF-C) .DELTA.Cys.sub.156 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2255378