Vascular endothelial growth factor-B and DNA coding therefor

Details Vascular endothelial growth factor-B and DNA coding therefor Vascular endothelial growth factor-B and DNA coding therefor

1995-06-06

1997-03-04

Fleisher, Mindy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, A61K 3818, C07K 14475

Patent

active

056079184

ABSTRACT:
VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.

REFERENCES:
Klagsburn et al, Ann. Rev. Physiology, 1991, vol. 53: pp. 217-239.
Ferrara et al., J. of Cellular Biochem., 1991, vol. 47: pp. 211-218.
Folkman et al, J. of Biological Chem., Jun., 1992, vol. 267 (16): pp. 10931-10934.

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