Vascular endothelial growth factor-b and dna coding therefor

Details Vascular endothelial growth factor-b and dna coding therefor Vascular endothelial growth factor-b and dna coding therefor

1995-12-06

1999-07-27

McKelvey, Terry A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435243, 4353201, 435348, 435366, 435410, 536 231, 536 235, 536 2433, C12N 510, C12N 100, C12N 1512, C12N 1563

Patent

active

059289392

ABSTRACT:
VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.

REFERENCES:
patent: 5607918 (1997-03-01), Eriksson et al.
Olofsson et al., "Vascular Endothelial Growth Factor B, a Novel Growth Factor Endothelial Cells", Proc. Natl. Acad. Sci. USA, vol. 93, pp. 2576-2581 (1996).
Orlandini et al., "Identification of a c-fos-Induced Gene That is Related to the Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor Family", Proc. Natl. Acad. Sci. USA, vol. 93, pp. 11675-11680 (1996).
Ngo et al, The Protein Folding Problem and Tertiary Structure Prediction, Mertz et al (eds.), 1994, Birkhauser, Boston, MA, pp. 433 and 492-495.

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