Vascular endothelial growth factor-B

Details Vascular endothelial growth factor-B Vascular endothelial growth factor-B

1996-03-01

1998-11-24

McKelvey, Terry A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, A61K 3818, C07K 14515

Patent

active

058406930

ABSTRACT:
VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.

REFERENCES:
patent: 5607918 (1997-03-01), Eriksson et al.
Olofsson et al., "Vascular Endothelial Growth Factor B, a Novel Growth Factor Endothelial Cells", Proc. Natl. Acad. Sci. USA, vol. 93, pp. 2576-2581 (1996).
Orlandini et al., "Identification of a c-fos-Induced Gene That is Related to the Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor Family", Proc. Natl. Acad. Sci. USA, vol. 93, pp. 11675-11680 (1996).
Ngo et al, The Protein Folding Problem and Tertiary Structure Prediction, 1994, Mertz et al (eds), Birkhauser, Boston, MA, pp. 433 and 492-495.

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