Vascular endothelial growth factor 2 and methods of use

Details Vascular endothelial growth factor 2 and methods of use Vascular endothelial growth factor 2 and methods of use

2006-12-26

2006-12-26

Landsman, Robert S. (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C530S350000, C530S399000

Reexamination Certificate

active

07153827

ABSTRACT:
Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

REFERENCES:
patent: 5073492 (1991-12-01), Chen et al.
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5219739 (1993-06-01), Tischer et al.
patent: 5234908 (1993-08-01), Szabo et al.
patent: 5240848 (1993-08-01), Keck et al.
patent: 5283354 (1994-02-01), Lemischka
patent: 5326695 (1994-07-01), Andersson et al.
patent: 5607918 (1997-03-01), Eriksson et al.
patent: 5633147 (1997-05-01), Meissner et al.
patent: 5652225 (1997-07-01), Isner
patent: 5661133 (1997-08-01), Leiden et al.
patent: 5693622 (1997-12-01), Wolff et al.
patent: 5776755 (1998-07-01), Alitalo et al.
patent: 5792453 (1998-08-01), Hammond et al.
patent: 5840693 (1998-11-01), Eriksson et al.
patent: 5861301 (1999-01-01), Terman et al.
patent: 5932540 (1999-08-01), Hu et al.
patent: 5935820 (1999-08-01), Hu et al.
patent: 6040157 (2000-03-01), Hu et al.
patent: 6121246 (2000-09-01), Isner
patent: 6130071 (2000-10-01), Alitalo et al.
patent: 6221839 (2001-04-01), Alitalo et al.
patent: 6245530 (2001-06-01), Alitalo et al.
patent: 6361946 (2002-03-01), Alitalo et al.
patent: 6403088 (2002-06-01), Alitalo et al.
patent: 6451764 (2002-09-01), Lee et al.
patent: 6645933 (2003-11-01), Alitalo et al.
patent: 6734285 (2004-05-01), Hu et al.
patent: 2002/0120123 (2002-08-01), Rosen et al.
patent: 2004/0143103 (2004-07-01), Hu et al.
patent: 2006/0014252 (2006-01-01), Lyman
patent: 710696 (1999-09-01), None
patent: B-70128/96 (1999-09-01), None
patent: 0 186 084 (1986-07-01), None
patent: 0 399 816 (1990-11-01), None
patent: 0476983 (1992-03-01), None
patent: 0476983 (1992-03-01), None
patent: 0 506 477 (1992-06-01), None
patent: 0506477 (1992-09-01), None
patent: 64-38100 (1989-02-01), None
patent: 2-117698 (1990-05-01), None
patent: WO 91/02058 (1991-02-01), None
patent: WO 921/4748 (1992-09-01), None
patent: WO 94/11506 (1994-05-01), None
patent: WO 95/19985 (1995-07-01), None
patent: WO 95/24414 (1995-09-01), None
patent: WO-95/24473 (1995-09-01), None
patent: WO 96/05856 (1996-02-01), None
patent: WO 96/39515 (1996-12-01), None
patent: WO-97/00271 (1997-01-01), None
patent: 9705250 (1997-02-01), None
patent: WO 97/05250 (1997-02-01), None
patent: 9709427 (1997-03-01), None
patent: WO-97/08320 (1997-03-01), None
patent: WO 97/09427 (1997-03-01), None
patent: 9717442 (1997-05-01), None
patent: WO 97/17442 (1997-05-01), None
patent: WO-97/19694 (1997-06-01), None
patent: WO 98/06844 (1998-02-01), None
patent: WO 98/07832 (1998-02-01), None
patent: WO 98/24811 (1998-06-01), None
patent: WO 98/33917 (1998-06-01), None
patent: WO 98/39035 (1998-09-01), None
patent: WO 98/49300 (1998-11-01), None
patent: WO 98/55619 (1998-12-01), None
patent: WO 98/56936 (1998-12-01), None
patent: WO 99/02545 (1999-01-01), None
patent: WO 99/08522 (1999-02-01), None
patent: WO 99/20749 (1999-04-01), None
patent: WO 99/21590 (1999-05-01), None
patent: 99/46364 (1999-09-01), None
patent: WO 99/46364 (1999-09-01), None
patent: WO 00/45835 (2000-08-01), None
patent: WO 00/73430 (2000-12-01), None
patent: WO 00/75163 (2000-12-01), None
patent: WO 01/57226 (2001-08-01), None
patent: WO 01/58956 (2001-08-01), None
patent: WO 02/11769 (2002-02-01), None
patent: WO 02/083704 (2002-10-01), None
patent: WO 02/083849 (2002-10-01), None
patent: WO 02/083850 (2002-10-01), None
patent: WO 03/097660 (2003-11-01), None
patent: 9-403464 (1996-01-01), None
Paulsson G. et al. Accession No. S08167. J. Molecular Biol. 211:331-349, 1990.
Eichmann, A., et al., Development 125(4):743-752 (1998).
Pajusola, K., et al., Cancer Research. 52:5738-5743 (1992).
Pajusola, K., et al., Oncogene 8:2931-2937 (1993).
Tischer, et al., Biochemical and Biophysical Research Communications 165(3):1198-1206 (1989).
Leung, D.W., et al., Science 246:1306-1309 (1989).
Breier, G., et al., Development 114:521-532 (1992).
Ferrara, et al., Journal of Cellular Biochemistry 47:211-218 (1991).
George et al., Macromolecular Seq. and Syn. Selected Meth—Application, pp. 127-149 (1988).
U.S. Appl. No. 08/340,011, filed Nov. 1994.
U.S. Appl. No. 08/510,133, filed Aug. 1995.
U.S. Appl. No. 08/585,895, filed Jan. 1996.
U.S. Appl. No. 08/601,132, filed Feb. 1996.
U.S. Appl. No. 08/671,573, filed Jun. 1996.
U.S. Appl. No. 08/554,374, filed Nov. 1995.
U.S. Appl. No. 60/03491, filed Sep. 1995.
Betsholtz et al., Nature 320:695-699 (1986).
Claffey et al., J. Biol. Chem. 267(23):16317-16322 (1992).
Corson et al., Genomics 17:476-484 (1993).
Dignam et al., Gene 88:133-140 (1990).
Ferrara et al., Endocrine Rev. 13(1):18-32 (1992).
Finnerty et al., Oncogene, 8(11): 2293-2298 (1993).
Heldin et al. Growth Factors 8:245-252 (1993).
Hu et al., FASEB J., 11:498-504 (1997).
Joukov et al., EMBO J. 15(2):290-298 (1996).
Joukov et al., EMBO J. 16(13):3898-3911 (1997).
Kaipainen et al., J. Exp. Med. 178:2077-2088 (1993).
Keck et al., Science 246: 1309 (1989).
Kingsley, D., Genes & Development 8:133-146 (1994).
Kukk et al., Development, 122: 3829-37 (1996).
Lee et al, Proc. Natl. Acad. Sci. (USA), 93:1988-1992 (1996).
Maglione et al., Oncogene 8:925-931 (1993).
Maglione et al., Proc. Natl. Acad. Sci. (USA), 88:9267-9271 (1991).
Massague, J. Annu. Rev. Cell Biol. 6:597-641 (1990).
Matthews et al., Proc. Natl. Acad. Sci. (USA), 88:9026-9030 (1991).
Millauer et al., Cell 72:835-846 (1993).
Millauer et al., Nature 367:576-579 (1994).
Oltvai et al., Cell, 74:609-619 (1993).
Paulsson et al., J. Mol. Biol. 211:331-349 (1990).
Tanaka et al., Mol. Cell Biol. 7(5):1978-1983 (1987).
Terman et al., Oncogene 6:1677-1683 (1991).
Terman et al., Biochem. Biophys. Res. Commun. 187(3):1579-1586 (1992).
Tischer et. al., J. Biol.Chem. 266(18):11947-11954 (1991).
Tsujimoto et al., Proc. Natl. Acad. Sci (USA), 83:5214-5218 (1986).
GenBank Accession No. X68203 (1993).
GenBank Accession No. M95200 (1992).
GenBank Accession No. M24160 (1989).
GenBank Accession No. M24276 (1989).
GenBank Accession No. M24277 (1989).
GenBank Accession No. D88689 (1993).
GenBank Accession No. L07296 (1993).
GenBank Accession No. X54936 (1991).
GenBank Accession No. S57152 (1993).
GenBank Accession No. X59397 (1991).
GenBank Accession No. X52263 (1992).
GenBank Accession No. M63971 (1991).
GenBank Accession No. M63972 (1991).
GenBank Accession No. M63973 (1991).
GenBank Accession No. M63974 (1991).
GenBank Accession No. M63975 (1991).
GenBank Accession No. M63976 (1991).
GenBank Accession No. M63977 (1991).
GenBank Accession No. M63978 (1991).
GenBank Accession No. M27281 (1990).
GenBank Accession No. X04571 (1995).
GenBank Accession No. X63556 (1997).
GenBank Accession No. L19896 (1994).
GenBank Accession No. L04947 (1995).
GenBank Accession No. M16237 (1995).
GenBank Accession No. M16243 (1995).
GenBank Accession No. M16244 (1995).
GenBank Accession No. M16245 (1995).
GenBank Accession No. K03212 (1995).
GenBank Accession No. K03213 (1995).
GenBank Accession No. K03214 (1995).
GenBank Accession No. K03215 (1995).
GenBank Accession No. K03216 (1995).
GenBank Accession No. K03217 (1995).
GenBank Accession No. K03218 (1995).
GenBank Accession No. M13994 (1994).
GenBank Accession No. M13995 (1994).
GenBank Accession No. L22473 (1993).
GenBank Accession No. L22474 (1993).
GenBank Accession No. AJ000185 (1998).
International Search Report, Application No. PCT/US99/05021.
International Search Report, Application No. PCT/US94/05291.
Achen, et al., Proc. Natl. Acad. Sci. (USA), 95(2): 548-553 (1998).
Andersson et al., J. Biol. Chem., 267(16):11260-11266 (1992).
Aprelikova et al., Cancer Research, 52:746-748 (1992).
Bell et al., Nucl.

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