Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-09-25
2007-09-25
Qian, Celine (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000, C435S455000
Reexamination Certificate
active
09921143
ABSTRACT:
Disclosed are human VEGF-2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF-2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides and polynucleotides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
REFERENCES:
patent: 5073492 (1991-12-01), Chen et al.
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5219739 (1993-06-01), Tischer et al.
patent: 5234908 (1993-08-01), Szabo et al.
patent: 5240848 (1993-08-01), Keck et al.
patent: 5283354 (1994-02-01), Lemischka
patent: 5326695 (1994-07-01), Andersson et al.
patent: 5607918 (1997-03-01), Eriksson et al.
patent: 5633147 (1997-05-01), Meissner et al.
patent: 5652225 (1997-07-01), Isner
patent: 5661133 (1997-08-01), Leiden and Barr
patent: 5693622 (1997-12-01), Wolff et al.
patent: 5776755 (1998-07-01), Alitalo et al.
patent: 5792453 (1998-08-01), Hammond et al.
patent: 5840693 (1998-11-01), Eriksson et al.
patent: 5861301 (1999-01-01), Terman et al.
patent: 5932540 (1999-08-01), Hu et al.
patent: 5935820 (1999-08-01), Hu et al.
patent: 6040157 (2000-03-01), Hu et al.
patent: 6121246 (2000-09-01), Isner
patent: 6130071 (2000-10-01), Alitalo et al.
patent: 6221839 (2001-04-01), Alitalo et al.
patent: 6245530 (2001-06-01), Alitalo et al.
patent: 6297238 (2001-10-01), Doyle et al.
patent: 6361946 (2002-03-01), Alitalo and Joukov
patent: 6403088 (2002-06-01), Alitalo et al.
patent: 6451764 (2002-09-01), Lee and Wood
patent: 6515105 (2003-02-01), Alitalo et al.
patent: 6645933 (2003-11-01), Alitalo and Joukov
patent: 6660744 (2003-12-01), Hirst et al.
patent: 6713474 (2004-03-01), Hirst et al.
patent: 6764820 (2004-07-01), Ferrell et al.
patent: 6824777 (2004-11-01), Alitalo et al.
patent: 2002/0013261 (2002-01-01), Pawliuk et al.
patent: 2002/0019350 (2002-02-01), Levine et al.
patent: 2002/0034501 (2002-03-01), Pawliuk et al.
patent: 2002/0086004 (2002-07-01), Adnot et al.
patent: 2002/0111362 (2002-08-01), Rubinfeld
patent: 2002/0151489 (2002-10-01), Gravereaux et al.
patent: 2002/0155421 (2002-10-01), Kearney et al.
patent: 2002/0156081 (2002-10-01), Hirst et al.
patent: 2003/0103943 (2003-06-01), Rosengart et al.
patent: 2003/0125523 (2003-07-01), Alitalo et al.
patent: 2003/0153752 (2003-08-01), Hirst et al.
patent: 2003/0165464 (2003-09-01), Enholm et al.
patent: 2003/0180286 (2003-09-01), Carmeliet et al.
patent: 2003/0187001 (2003-10-01), Calderwood et al.
patent: 2003/0211988 (2003-11-01), Epstein
patent: 2004/0002140 (2004-01-01), Gilbert et al.
patent: 2004/0006083 (2004-01-01), Hirst et al.
patent: 2004/0031067 (2004-02-01), Herlyn et al.
patent: 2004/0248781 (2004-12-01), Kerbel
patent: 2005/0118180 (2005-06-01), Rubinfeld
patent: 2006/0014252 (2006-01-01), Lyman
patent: 710696 (1999-09-01), None
patent: 0 186 084 (1986-07-01), None
patent: 0 399 816 (1990-11-01), None
patent: 0 476983 (1992-03-01), None
patent: 0-476983 (1992-03-01), None
patent: 0476983 (1992-03-01), None
patent: 0-506477 (1992-09-01), None
patent: 64-38100 (1989-02-01), None
patent: 2-117698 (1990-05-01), None
patent: WO-91/02058 (1991-02-01), None
patent: WO92/14748 (1992-09-01), None
patent: 94/11506 (1994-05-01), None
patent: WO95/19985 (1995-07-01), None
patent: WO95/24414 (1995-09-01), None
patent: WO-95/24473 (1995-09-01), None
patent: WO95/24473 (1995-12-01), None
patent: WO96/05856 (1996-02-01), None
patent: WO 96/39515 (1996-12-01), None
patent: WO96/39515 (1996-12-01), None
patent: WO-97/00271 (1997-01-01), None
patent: WO97/05250 (1997-02-01), None
patent: WO97/09427 (1997-03-01), None
patent: 97/17442 (1997-05-01), None
patent: WO-97/19694 (1997-06-01), None
patent: WO98/06844 (1998-02-01), None
patent: WO98/07832 (1998-02-01), None
patent: WO98/24811 (1998-06-01), None
patent: WO98/33917 (1998-06-01), None
patent: WO98/39035 (1998-09-01), None
patent: WO98/49300 (1998-11-01), None
patent: WO-98/55619 (1998-12-01), None
patent: WO98/56936 (1998-12-01), None
patent: WO-99/02545 (1999-01-01), None
patent: WO99/08522 (1999-02-01), None
patent: WO-99/20749 (1999-04-01), None
patent: WO99/21590 (1999-05-01), None
patent: WO99/46364 (1999-09-01), None
patent: 00/21560 (2000-04-01), None
patent: 00/24412 (2000-05-01), None
patent: 00/45835 (2000-08-01), None
patent: 00/58511 (2000-10-01), None
patent: 00/61186 (2000-10-01), None
patent: 00/62798 (2000-10-01), None
patent: WO-00/73430 (2000-12-01), None
patent: WO 00/75163 (2000-12-01), None
patent: 01/52904 (2001-07-01), None
patent: WO-01/57226 (2001-08-01), None
patent: WO-01/58956 (2001-08-01), None
patent: 02/11769 (2002-02-01), None
patent: 02/083704 (2002-10-01), None
patent: 02/083849 (2002-10-01), None
patent: 02/083850 (2002-10-01), None
patent: 03/000009 (2003-01-01), None
patent: 03/015755 (2003-02-01), None
patent: 03/097660 (2003-11-01), None
patent: WO-97/08320 (2004-03-01), None
patent: 9-403464 (1996-01-01), None
Vale, P et al. Percutaneous electromechanical mapping demonstrates efficacy of pVGI.1(VEGF2) in an animal model of chronic myocardial ischemia. Circulation, Nov. 2, 1999. vol. 100, No. 18 suppl., pp. I.22.
Verma et al. (1997, Nature, vol. 389, pp. 239-242).
Anderson et al.(1998, Nature, vol. 392, pp. 25-30).
Manniatis et al. Molecular Cloning: A Laboratory Manual. 1982. Cold Spring Harbor Laboratory. Chapter 8, pp. 248-251.
International Search Report, Application No. PCT/US02/26246, mailed May 21, 2003.
Statutory Declaration of Kari Alitalo, executed on Aug. 14, 2002, and accompanying Exhibits KA-1 and KA-2.
Statutory Declaration of Peter Adrian Walton Rogers, executed on Aug. 9, 2002.
Statutory Declaration of Francis John Ballard, executed on Jul. 16, 2002.
Statutory Declaration of Kari Alitalo, executed on Jul. 16, 2002, and accompanying Exhibit 1.
Statutory Declaration of Susan Power, executed on Mar. 22, 2002, and accompanying Appendices I to IV.
Statutory Declaration of Nicholas Kim Hayward, executed on Mar. 26, 2002.
Statutory Declaration of Stuart A. Aaronson, executed on Mar. 22, 2002, and accompanying Appendices I to III.
Statutory Declaration of Gary Baxter Cox, executed on Mar. 22, 2002, and accompanying Exhibit GBC24 (Statutory Declaration of Peter Adrian Walters, executed on Oct. 26, 2001).
Statutory Declaration of Frances John Ballard, executed on Dec. 12, 2001, and accompanying Exhibit 1.
Statutory Declaration of Kari Alitalo, executed on Sep. 24, 2001, and accompanying Exhibits 1 and 2.
Statutory Declaration of Peter Adrian Walton Rogers, executed on Nov. 12, 2001, and accompanying Exhibits PAWR1 to PAWR14.
Statutory Declaration of John Stanley Mattick, executed on Dec. 12, 2000, and accompanying Exhibits JSM1 to JSM4.
Statutory Declaration of Nicholas Kim Hayward, executed on Dec. 8, 2000, and accompanying Exhibits NKH1 and 2.
Statutory Declaration of Jennifer Ruth Gamble, executed on Dec. 12, 2000, and accompany Exhibits JRG 1 to 3.
Statutory Declaration of Tom Rapoport, executed on Dec. 13, 2000, and accompanying Exhibits TP 1 and 2.
Statutory Declaration of Stuart A. Aaronson, executed on Dec. 14, 2000, and accompanying CV.
Statutory Declaration of Susan Power, executed on Dec. 13, 2000, and accompanying Appendices 1 to 2 and F161.
Statutory Declaration of Gary Baxter Cox, executed on Dec. 13, 2000, and accompanying Exhibits GBC 1 to 23.
Statutory Declaration of Peter Adrian Walton Rogers, executed on Feb. 16, 2000, and accompanying Exhibits 1.
Statutory Declaration of Frances John Ballard, executed on Feb. 16, 2000, and accompanying Exhibit 1.
Statutory Declaration of Kari Alitalo, executed on Feb. 15, 2000, and accompanying Exhibits 1 to 3.
U.S. Appl. No. 08/510,133, filed Aug. 1995.
U.S. Appl. No. 08/585,895, filed Jan. 1996.
U.S. Appl. No. 08/601,132, filed Feb. 1996.
U.S. Appl. No. 08/671,573
Human Genome Science, Inc.
Qian Celine
Sterne Kessler Goldstein & Fox P.L.L.C.
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