Vascular adhesion protein-(VAP-1) and VAP-1-specific antibodies

Details Vascular adhesion protein-(VAP-1) and VAP-1-specific antibodies Vascular adhesion protein-(VAP-1) and VAP-1-specific antibodies

1994-09-15

1996-12-03

Parr, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 7021, 4351722, 530300, 530350, 53038822, 530395, C12N 524, C07K 1400, C07K 1628

Patent

active

055807801

ABSTRACT:
A novel endothelial cell molecule, VAP-1, is described that mediates lymphocyte binding in man. Further described are anti-VAP-1 monoclonal antibodies and methods for the diagnosis and treatment of inflammatory and autoimmune diseases by the administration of VAP-1 binding compounds, such as anti-VAP-1 antibodies.

REFERENCES:
Airas et al., "Lymphocyte-Vascular Adhesion Protein-2 Is a Novel 70-kDa Molecule Involved in Lymphocyte Adhesion to Vascular Endothelium," J. Immunol. 151(8):4228-4238 (1993).
Balass et al., "Identification of a hexapeptide that mimics a conformation-dependent binding site of acetylcholine receptor by use of a phage-epitope library," PNAS USA 90:10638-10642 (1993).
Berg et al., "The Human Peripheral Lymph Node Vascular Addressin is a Ligand for LECAM-1, the Peripheral Lymph Node Homing Receptor," J. Cell Biol. 114(2):343-349 (1991).
Bevilacqua et al., "Identification of an inducible endothelial-leukocyte adhesion molecule," PNAS USA 84:9238-9242 (1987).
Butcher et al., "Leukocyte-Endothelial Cell Recognition: Three (or More) Steps to Specificity and Diversity," Cell 67:1033-1036 (1991).
Cotran et al., "Induction and Detection of a Human Endothelial Activation Antigen In Vivo," J. Exp. Med. 164:661-666 (1986).
de Fougerolles et al., "Characterization of ICAM-2 and Evidence for a Third Counter-Receptor for LFA-1," J. Exp. Med. 174:253-267 (1991).
Freeman et al., "An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors," PNAS USA 87:8810-8814 (1990).
Friedman et al., "Cloning and characterization of cyclophilin C-associated protein: A candidate natural cellular ligand for cyclophilin C," PNAS USA 90:6815-6819 (1993).
Geoffroy et al., "Evidence for a Distinct Lymphocyte Homing Specificity Involved in Lymphocyte Migration to Lung-Associated Lymph Nodes," FASEB J. 2:A667, Abstract No. 2152 (1988).
Harris and Emery, "Therapeutic Antibodies -- the coming of age," TiBTECH 11:42-46 (1993).
Hattori et al., "Stimulated Secretion of Endothelial von Willebrand Factor is Accompanied by Rapid Redistribution to the Cell Surface of the Intracellular Granule Membrane Protein GMP-140," J. Biol. Chem. 264(14):7768-7771 (1989).
Jalkanen et al., "A Distinct Endothelial Cell Recognition System that Controls Lymphocyte Traffic into Inflamed Synovium," Science 233:556-558 (1986).
Jalkanen et al., "In Vitro Analysis of the Homing Properties of Human Lymphocytes: Developmental Regulation of Functional Receptors for High Endothelial Venules," Blood 66(3):577-582 (1985).
Jalkanen et al., "A Novel Endothelial Cell Antigen Involved in Lymphocyte Binding to High Endothelial Venules," Keystone Symp. Mol. Cell. Biol., Suppl. 16F, p. 107, Abstract No. W610 (Apr. 3-16, 1992).
Osborn et al., "Direct Expression Cloning of Vascular Cell Adhesion Molecule 1, A Cytokine-Induced Endothelial Protein that Binds to Lymphocytes," Cell 59:1203-1211 (1989).
Osborn, L., "Leukocyte Adhesion to Endothelium in Inflammation," Cell 62:3-6 (1990).
Rice et al., "Vascular and Nonvascular Expression of INCAM-110, A Target for Mononuclear Leukocyte Adhesion in Normal and Inflamed Human Tissues," Amer. J. Pathol. 138(2):385-393 (1991).
Rosen et al., "Involvement of Sialic Acid on Endothelial Cells in Organ-Specific Lymphocyte Recirculation," Science 228:1005-1007 (1985).
Salmi and Jalkanen, "A 90-Kilodalton Endothelial Cell Molecule Mediating Lymphocyte Binding in Humans," Science 257:1407-1409 (1992).
Salmi et al., "A Novel Endothelial Cell Antigen Involved in Lymphocyte Binding to High Endothelial Venules," Eur. Fed. Immunol. Soc., 11th Meeting Abstracts, Abstract No. 21-12 (Jun. 9, 1991).
Salmi et al., "Induction and Function of Vascular Adhesion Protein-1 at Sites of Inflammation," J. Exp. Med. 178:2255-2260 (1993).
Stoolman, L. M., "Adhesion Molecules Controlling Lymphocyte Migration," Cell 56:907-910 (1989).
Wellicome et al., "A Monoclonal Antibody that Detects A Novel Antigen on Endothelial Cells that is Induced by Tumor Necrosis Factor, IL-1, or Lipopolysaccharide," J. Immunol. 144(7):2558-2565 (1990).

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