Various N-substituted 3-piperidine carboxylic acids or N-substit

Details Various N-substituted 3-piperidine carboxylic acids or N-substit Various N-substituted 3-piperidine carboxylic acids or N-substit

1987-10-14

1988-09-20

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514326, 514327, 514330, 514332, 514335, 514336, 514346, 514350, 514356, 546194, 546203, 546204, 546213, 546216, 546227, 546261, 546263, 546284, 546298, 546316, 546322, A61K 31445, A61K 3144, C07D21178, C07D21160

Patent

active

047726156

ABSTRACT:
Analogs of nipecotic acid are the novel compounds of the present invention. The analogs are GABA uptake inhibitors for use to treat epilepsy and, thus, the invention is also pharmaceutical compositions and methods of use therefor.

REFERENCES:
R. L. Krall, et al., Epilepsia, 19:409, (1978).
W. S. Schwark & W. Loscher, "Comparison of the Anticonvulsant Effects of Two Novel GABA Uptake Inhibitors & Diazepam in Amygdaloid Kindled Rats", Naunyn Schmiedeberg's Arch. Pharmacol., 329:367-71, (1985).
EP Search Report attached.

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