Various N-substituted 3-piperidine carboxylic acids or N-substit

Details Various N-substituted 3-piperidine carboxylic acids or N-substit Various N-substituted 3-piperidine carboxylic acids or N-substit

1991-05-21

1992-05-26

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21160

Patent

active

051169886

ABSTRACT:
Selected analogs of ninpecotic acid are the novel compounds of the present invention. The analogs are GABA uptake inhibitors for use to treat epilepsy and, thus, the invention is also pharmaceutical compositions and methods of use thereof.

REFERENCES:
patent: 692656 (1902-02-01), Harries
R. L. Krall, et al Epilepsia 19:409 (1978).
W. S. Schwark & W. Loscher "Comparison of the Anticonvulsant Effects of Two Novel GABA Uptake Inhibitors & Diazepam in Amygdaloid Kindled Rats" Naunyn Schmiedeberg's Arch. Pharmacol., 329:367-71 (1985).

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