Varicella-zoster virus as a live recombinant vaccine

Details Varicella-zoster virus as a live recombinant vaccine Varicella-zoster virus as a live recombinant vaccine

1992-02-27

1994-05-10

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352351, 4353001, 424 89, 935 32, 935 57, 935 65, C12N 1586, C12N 701, A61K 39295, A61K 3925

Patent

active

053106687

ABSTRACT:
A vaccine strain of varicella-zoster virus (VZV), tested in clinical trials, is capable of preventing chickenpox in children. This virus has been modified by the introduction into its genome of heterologous DNA which encodes an immunogenic polypeptide of another human pathogen. This heterologous polypeptide is expressed in cells infected by the recombinant virus. Such recombinant VZV is useful as a vaccine for chickenpox as well as for heterologous pathogens.

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