Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-03-01
2005-03-01
Myers, Carla J. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C536S023500
Reexamination Certificate
active
06861217
ABSTRACT:
A novel polymorphic site in the 5′ leader cistron of the β2-adrenergic receptor (β2AR) gene is disclosed. The polymorphisms present at this site result in different levels of inhibition of translation of β2AR mRNA. Compositions and methods for genotyping this polymorphic site as disclosed. In addition, methods for using this genotype information are disclosed, including predicting genetic predisposition to a disease modified by β2AR expression and predicting a patient's bronchodilating response to β2-agonists.
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Catlett Matthew M
Genaissance Pharmaceuticals, Inc.
Henderson Melodie W
University of Cincinnati
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