Variants of tissue plasminogen activator, compositions and metho

Details Variants of tissue plasminogen activator, compositions and metho Variants of tissue plasminogen activator, compositions and metho

1993-03-22

1995-01-31

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 435226, C12N 948, A61K 32547

Patent

active

053857321

ABSTRACT:
A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.

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