Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2003-06-25
2009-10-20
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S252300, C435S320100, C536S023200
Reexamination Certificate
active
07604970
ABSTRACT:
The present invention relates to novel variants of the PapM polypeptide of bacteria of theStreptomycesgenus which possess a substrate selectivity and/or an improved effectiveness compared to the wild-type polypeptide. It also relates to the nucleic acids encoding these variants, to the microorganisms which incorporate these nucleic acids and to their use for producing B components of Streptogramins.
REFERENCES:
patent: 6352839 (2002-03-01), Blanc
patent: WO 96/05219 (1996-02-01), None
Blanc, Veronique et al., Identification and analysis of genes fromStreptomyces pristinaespiralisencoding enzymes involved in the biosynthesis of the 4-dimethylamino-l-phenylalanine precursor of pristinamycin I, Molecular Microbiology, (1997), vol. 23, No. 2, pp. 191-202.
Bamas-Jacques Nathalie
Famechon Alain
Thibaut Denis
Aventis Pharma S.A.
Saidha Tekchand
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