Variants of the NK1 fragment of hepatocyte growth...

Details Variants of the NK1 fragment of hepatocyte growth... Variants of the NK1 fragment of hepatocyte growth...

2007-02-20

2007-02-20

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

10475616

ABSTRACT:
Variants of the NK1 fragment of the polypeptide growth factor HGF/SF which act as agonists of the MET receptor and their use are disclosed. The agonists comprise at least one substitution at positions equivalent to 132, 134, 170 and 181 of full length HGF/SF (SEQ ID NO:2) and these substitutions provide variants which show scatter factor activity and induce DNA synthesis. In vivo, the variants provide protection from liver damage in a model of acute liver failure.

REFERENCES:
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patent: WO 96/40914 (1996-12-01), None
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Leitha, et al., The EMBO Journal, 20:5543-5555 (2001).
John L. Jakubczak, et al., “NK1, A Natural Splice Variant of Hepatocyte Growth Factor/Scatter Factor, Is A Partial Agonist in Vivo,” Molecular & Cellular Biology, Mar. 1998 vol. 18, No. 3, p. 1275-1283.
Takafumi Nakamura et al., “Hepatoprotective Action of Adenovirus-Transferred HNF-3γ Gene in Acute Liver Injury Caused by CC14,” Federation of European Biochemical Societies, 1999, FEBS Letters 459, p. 1-4.
Cory M. Hogaboam et al., “Novel CXCR2-Dependent Liver Regenerative Qualities of ELR-Containing CXC Chemokines,” The FASEB Journal, vol. 13, Sep. 1999, p. 1565-1674.

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