Variants of the major allergen Phl p 1 from timothy grass

Details Variants of the major allergen Phl p 1 from timothy grass Variants of the major allergen Phl p 1 from timothy grass

2003-07-31

2010-06-08

Haddad, Maher M (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S275100, C514S002600, C530S300000, C530S350000

Reexamination Certificate

active

07731970

ABSTRACT:
The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterized in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof.

REFERENCES:
patent: 7001743 (2006-02-01), Cosgrove et al.
patent: 2002/0064530 (2002-05-01), Sturaro et al.
patent: WO 0222679 (2002-03-01), None
Focke et al. ‘Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination.’ Faseb J. EPUB Jul. 24, 2001, p. 1-25.
Schramm et al. ‘“ Allergen engineering”: variants of the timothy grass pollen allergen Phl p 5b with reduced IgE-binding capacity but conserved T cell reactivity.’ J. Immunol. 162:2406-2414, 1999.
Larche et al. ‘Immunological mechanisms of allergen-specific immunotherapy.’ Nature Reviews 6:761-771,2006.
Suck et al. ‘Bacterially expressed and optimized recombinant Phl p 1 is immunobiochemically equivalent to natural Phl p 1.’ Biochim Biophys. Acta.1764(11):1701-9, 2006.
Focke et al. ‘Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination.’ 15(11):2042-4. Epub Jul. 24, 2001.

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