Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1994-12-13
1996-05-28
Jacobson, Dian C.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 9463, 435226, A61K 3848, A61K 3849, C12N 948, C12N 964
Patent
active
055209114
ABSTRACT:
A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.
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Anderson Stephen
Brady Kevin M.
Keyt Bruce A.
Presta Leonard G.
Dreger Ginger R.
Genentech Inc.
Jacobson Dian C.
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