Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-05-05
2010-02-02
Spector, Lorraine (Department: 1647)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S070100, C435S252300, C435S419000, C530S399000
Reexamination Certificate
active
07655781
ABSTRACT:
The present invention provides human glycoprotein hormone (hGPH) α-chain splice variants, including isolated nucleic acids encoding these variants and the encoded amino acid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells comprising these sequences. The present invention further discloses the use of these sequences in the diagnosis, prevention and treatment of symptoms, diseases and disorders related to glycoprotein hormones.
REFERENCES:
patent: 5367110 (1994-11-01), Galili et al.
patent: 6242580 (2001-06-01), Boime et al.
patent: 6306654 (2001-10-01), Boime et al.
patent: 6361992 (2002-03-01), Szkudlinski et al.
patent: 6625545 (2003-09-01), Amitai et al.
patent: 6812339 (2004-11-01), Venter et al.
patent: 2002/0169292 (2002-11-01), Weintraub et al.
patent: 2004/0101876 (2004-05-01), Mintz et al.
patent: 2004/0142325 (2004-07-01), Mintz et al.
patent: WO 98/13469 (1998-02-01), None
Strausberg et al., NIH-MGC http:://MGC.NCI.NIH.GOV, Apr. 10, 2004, accessed Aug. 8, 2008.
Wu et al. “Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein”. Structure, vol. 2, Issue 6, Jun. 1994, pp. 545-558.
Shupnik et al., “Molecular biology of thyrotropin”. Endocr. Rev. vol. 10, 1989, pp. 459-475.
Baenziger JU 1994 “Glycosylation and glycoprotein hormone function.” In: Lustbander JW Puett D, Ruddon RW (eds) Glycoprotein hormones. Springer-Verlag, New York, pp. 167-174.
Fiddes et al., “The Gene Encoding the Common Alpha Subunit of the four Human Glycoprotein Hormones”. J. Mol. Appl. Gen. 1981; vol. 1 pp. 3-18.
Dirnhofer S. et al. “Free α subunit of human chorionic gonadotrophin: molecular basis of immunologically and biologically active domains”. Journal of Endocrinology 1994, 140: pp. 145-154.
Zygmunt M. et al. “Characterization of human chorionic gonadotropin as a novel angiogenic factor”.J Clin Endocrinol Metab. Nov. 2002;87(11): pp. 5290-5296.
Hellens P. et al., “pGreen: a versatile and flexible binary Ti vector for Agrobacterium-mediated plant transformation”. Plant Mol Biol. Apr. 2000;42(6): pp. 819-832.
Torres K.C. “Tissue culture techniques for horticultural crops”. p. 111-114; 169-173.
Wurtele et al., “A Simple Efficient method for the Agrobacterium-mediated transformation of carrot callus cells”. 1989, Plant Sci. 61: pp. 253-262.
Nasrallah, June B. et al “TheSGene family: Genes with Diverse structures and functions”. 1995, Methods Mol. Biol. 55: pp. 63-72.
Suh, B.S. et al. “Introduction of a gonadotropin receptor expression plasmid into immortalized granulosa cells leads to reconstitution of hormone-dependent steroidogenesis” . J Cell Biol. Oct. 1992;119(2):439-50.
Keren-Tal I. et al, “Establishment of steroidogenic granulosa cell lines expressing follicle stimulating hormone receptors”. Mol Cell Endocrinol. Sep. 1993;95(1-2):R1-10.
Amsterdam et al., “Generation and Application of Ovarian Steroidogenic Cell Lines”. 2004, In: The Ovary, Chapter 22, Elsevier press, pp. 389-409.
Gordon D. F. et al. “Organization and nucleotide sequence of the mouse alpha-subunit gene of the pituitary glycoprotein hormones”. DNA (New York). 1998:7(10): pp. 679-690.
Claverie J-M et al. “Alu alert”. Nature. Oct. 27, 1994;371: p. 752.
Freimuth R.R. et al. “Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chomosomal localization”. Genomics. Apr. 15, 2000;65(2): pp. 157-165.
Kawarabayasi Y. et al. “Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,Aeropyrum pernixK1”. DNA Res. Apr. 30, 1999;6(2):83-101.
“Embryogenesis In Carrot Cell Suspension Cultures” Cell Culture, pp. 169-173.
Baum Gideon
Bernstein Jeanne
Dahary Dvir
Shaaltiel Yoseph
Shalev Gil
Compugen Ltd.
Protalix Ltd.
Spector Lorraine
Winston & Strawn LLP
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